ENSG00000047365


Homo sapiens

Features
Gene ID: ENSG00000047365
  
Biological name :ARAP2
  
Synonyms : ARAP2 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 / Q8WZ64
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p14
Gene start: 35948221
Gene end: 36244509
  
Corresponding Affymetrix probe sets: 1561407_at (Human Genome U133 Plus 2.0 Array)   213618_at (Human Genome U133 Plus 2.0 Array)   242402_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000302895
Ensembl peptide - ENSP00000481036
Ensembl peptide - ENSP00000423886
Ensembl peptide - ENSP00000422731
NCBI entrez gene - 116984     See in Manteia.
OMIM - 606645
RefSeq - XM_017007700
RefSeq - XM_017007701
RefSeq - XM_017007702
RefSeq - NM_015230
RefSeq - XM_017007698
RefSeq - XM_017007699
RefSeq Peptide - NP_056045
swissprot - Q8WZ64
swissprot - D6RAD6
swissprot - A0A0C4DGW1
swissprot - D6RC39
Ensembl - ENSG00000047365
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR387919.1ENSDARG00000100518Danio rerio
 ARAP2ENSGALG00000041373Gallus gallus
 Arap2ENSMUSG00000037999Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARAP3 / Q8WWN8 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3ENSG0000012031831
ARAP1 / Q96P48 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1ENSG0000018663531
Q13017 / ARHGAP5 / Rho GTPase activating protein 5ENSG0000010085211
Q9NRY4 / ARHGAP35 / Rho GTPase activating protein 35ENSG0000016000711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000198  Rho GTPase-activating protein domain
 IPR001164  Arf GTPase activating protein
 IPR001660  Sterile alpha motif domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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