ENSGALG00000011531


Gallus gallus

Features
Gene ID: ENSGALG00000011531
  
Biological name :APAF1
  
Synonyms : APAF1 / apoptotic peptidase activating factor 1
  
Possible biological names infered from orthology : Apoptotic protease-activating factor 1 / O14727 / O88879
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 46718811
Gene end: 46744193
  
Corresponding Affymetrix probe sets: Gga.15359.1.S1_at (Chicken Array)   GgaAffx.23578.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000037437
NCBI entrez gene - 417926     See in Manteia.
RefSeq - XM_416167
swissprot - F1P1P3
Ensembl - ENSGALG00000011531
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apaf1ENSDARG00000021239Danio rerio
 APAF1ENSG00000120868Homo sapiens
 Apaf1ENSMUSG00000019979Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WDSUB1 / WD repeat, sterile alpha motif and U-box domain containing 1 / Q8N9V3* / Q9D0I6* / WD repeat, SAM and U-box domain containing 1*ENSGALG000000125746
WDR88 / WD repeat domain 88 / Q6ZMY6*ENSGALG000000422984


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001680  WD40 repeat
 IPR002182  NB-ARC
 IPR011029  Death-like domain superfamily
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017251  Apoptotic protease-activating factor 1
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:1902510 regulation of apoptotic DNA fragmentation IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043293 apoptosome IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043531 ADP binding IEA


Pathways (from Reactome)
Pathway description
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011020 CYCS / P67881 / Cytochrome c / P99999* / P62897* / Gm10053* / predicted gene 10053* / cytochrome c, somatic*  / reaction / complex
 ENSGALG00000001366 CASP9 / caspase 9 / P55211* / Q8C3Q9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*  / reaction / complex






 

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