ENSMUSG00000019979


Mus musculus

Features
Gene ID: ENSMUSG00000019979
  
Biological name :Apaf1
  
Synonyms : Apaf1 / Apoptotic protease-activating factor 1 / O88879
  
Possible biological names infered from orthology : apoptotic peptidase activating factor 1 / O14727
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C2
Gene start: 90989311
Gene end: 91082770
  
Corresponding Affymetrix probe sets: 10371846 (MoGene1.0st)   1450223_at (Mouse Genome 430 2.0 Array)   1452870_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124422
Ensembl peptide - ENSMUSP00000020157
Ensembl peptide - ENSMUSP00000124134
Ensembl peptide - ENSMUSP00000124968
Ensembl peptide - ENSMUSP00000125291
NCBI entrez gene - 11783     See in Manteia.
MGI - MGI:1306796
RefSeq - NM_001042558
RefSeq - NM_001282947
RefSeq - NM_009684
RefSeq Peptide - NP_001036023
RefSeq Peptide - NP_001269876
RefSeq Peptide - NP_033814
swissprot - Q80VR5
swissprot - G3XA09
swissprot - O88879
Ensembl - ENSMUSG00000019979
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apaf1ENSDARG00000021239Danio rerio
 APAF1ENSGALG00000011531Gallus gallus
 APAF1ENSG00000120868Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D0I6 / Wdsub1 / WD repeat, SAM and U-box domain containing 1 / Q8N9V3* / WD repeat, sterile alpha motif and U-box domain containing 1*ENSMUSG000000269887


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001680  WD40 repeat
 IPR002182  NB-ARC
 IPR011029  Death-like domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017251  Apoptotic protease-activating factor 1
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036322  WD40-repeat-containing domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IEA
 biological_processGO:0010659 cardiac muscle cell apoptotic process IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0034349 glial cell apoptotic process IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051402 neuron apoptotic process IGI
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:1902510 regulation of apoptotic DNA fragmentation IGI
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043293 apoptosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IPI
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043531 ADP binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0000075 absent neurocranium "missing bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000099 absent vomer bone "missing triangular flat bone of the nasal septum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000101 absent ethmoidal bone "missing midline facial bone that encloses the nasal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000105 defective ossification of basisphenoid "abnormal formation of the bone at the base of the sphenoid bone; arises from an ossification center independent of the remainder of the sphenoid bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apaf1fog/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Apaf1fog/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

Allelic Composition: Apaf1fog/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr,Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000792 abnormal cortical marginal zone morphology 
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000821 choroid plexus hyperplasia "increased cell number in the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0000828 abnormal fourth ventricle morphology "malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apaf1fog/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000831 diencephalon hyperplasia "increased cell number in the rostral portion of the brain stem" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0000833 thalamus hyperplasia "increased cell number in the thalamus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49481]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0000839 hypothalamus hyperplasia "increased cell number in the hypothalamus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0000898 midbrain hyperplasia "increased cell number associated with the middle of the three cerebral vesicles of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Pax66Neu/Pax6+
Genetic Background: involves: 102 * C3H

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

Allelic Composition: Apaf1fog/Apaf1tm1Her
Genetic Background: involves: 129S6/SvEvTac * C3H/HeJ * C57BL/6

Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Apaf1fog/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000919 cranioschisis "incomplete closure of the skull, usually congenital " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Apaf1fog/Apaf1tm1Her
Genetic Background: involves: 129S6/SvEvTac * C3H/HeJ * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000935 abnormal folding of telencephalic vesicles "malformation of the stereotypic invaginations forming the paired diverticula of the telencephalon" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cops5tm1Rpar/Cops5tm1Rpar,Tg(Lck-cre)548Jxm/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Apaf1fog/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeJ * NMRI

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001308 abnormal lens polarity "failure of normal orientation of the lens during development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001329 retina hyperplasia "greater than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Ptch1tm1Kmmt/Ptch1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax66Neu/Pax6+
Genetic Background: involves: 102 * C3H

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax66Neu/Pax6+
Genetic Background: involves: 102 * C3H

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Pax66Neu/Pax6+
Genetic Background: involves: 102 * C3H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002239 abnormal nasal septum morphology "any structural anomaly of the structure that separates the two nasal cavities " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Apaf1fog/Apaf1tm1Mak
Genetic Background: involves: 129S6/SvEvTac * C3H/HeJ * CD-1

Allelic Composition: Apaf1fog/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeJ * NMRI

Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

Allelic Composition: Apaf1fog/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr,Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr,Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Aifm1Hq/Aifm1Hq,Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Apaf1fog/Apaf1tm1Mak
Genetic Background: involves: 129S6/SvEvTac * C3H/HeJ * CD-1

Allelic Composition: Apaf1fog/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeJ * NMRI

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1fog/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0004203 abnormal cranial flexure "any structural abnormality or absence of the sharp, ventrally concave bend in the developing midbrain of the embryo" [J:10730, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0004327 increased vestibular hair cell number "increased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004383 absent interparietal bone "absence of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004407 increased cochlear hair cell number "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004419 absent parietal bone "absence of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004443 absent supraoccipital bone "absence of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004448 abnormal presphenoid bone morphology "any structural anomaly of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004449 absent presphenoid bone "absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005274 abnormal viscerocranium morphology "anomalous structure or formation of the part of the skull that comprises the facial bones " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005297 spina bifida occulta "common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0006030 abnormal otic vesicle formation "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr,Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1fog/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0009889 persistence of medial edge epithelium during palatal shelf fusion "palatal shelves meet at the midline during development but do not adhere along the medial edge epithelia, and fail to form the midline epithelial seam" [PMID:16680722]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0012174 flat head "the appearance of a flattened surface outline or contour of a normally rounded head of an organism" [MGI:anna]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0012260 encephalomeningocele "hernial protrusion of the brain and its meninges through an opening or defect in the skull, most often occuring in the occipital region" [ISBN:0-683-40008-8]
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Allelic Composition: Apaf1fog/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0012702 increased embryonic neuroepithelium thickness "increased width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0013500 abnormal fibroblast apoptosis "change in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0030045 abnormal forehead shape "any anomaly in the characteristic surface outline or contour of the forehead" [MGI:anna]
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Allelic Composition: Apaf1fog/Apaf1fog
Genetic Background: involves: C3H/HeJ

 MP:0030069 broad face "increased width of the upper and lower face" [MGI:anna]
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Allelic Composition: Apaf1fog/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0030251 broad frontonasal prominence "increased width of the unpaired embryonic process that is formed from the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [MGI:anna]
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Allelic Composition: Apaf1ytj/Apaf1ytj
Genetic Background: involves: C3H/HeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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