ENSDARG00000021239


Danio rerio

Features
Gene ID: ENSDARG00000021239
  
Biological name :apaf1
  
Synonyms : apaf1 / apoptotic peptidase activating factor 1
  
Possible biological names infered from orthology : Apoptotic protease-activating factor 1 / O14727 / O88879
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 17843717
Gene end: 17874048
  
Corresponding Affymetrix probe sets: Dr.10209.1.S1_at (Zebrafish Array)   Dr.13684.2.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000008347
Ensembl peptide - ENSDARP00000097917
NCBI entrez gene - 58131     See in Manteia.
swissprot - A5WVJ8
swissprot - F1QQ06
ZFIN ID - ZDB-GENE-000616-4
Ensembl - ENSDARG00000021239
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APAF1ENSGALG00000011531Gallus gallus
 APAF1ENSG00000120868Homo sapiens
 Apaf1ENSMUSG00000019979Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A0AUS0 / wdsub1 / WD repeat, sterile alpha motif and U-box domain containing 1 / Q8N9V3*ENSDARG000000904186


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001680  WD40 repeat
 IPR002182  NB-ARC
 IPR011029  Death-like domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017251  Apoptotic protease-activating factor 1
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043293 apoptosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0043531 ADP binding IEA


Pathways (from Reactome)
Pathway description
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004325 casp9 / caspase 9, apoptosis-related cysteine peptidase / P55211* / Q8C3Q9* / caspase 9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*  / reaction / complex






 

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