ENSDARG00000004325


Danio rerio

Features
Gene ID: ENSDARG00000004325
  
Biological name :casp9
  
Synonyms : casp9 / caspase 9, apoptosis-related cysteine peptidase
  
Possible biological names infered from orthology : caspase 9 / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211 / Q8C3Q9
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 24973773
Gene end: 24985272
  
Corresponding Affymetrix probe sets: Dr.16035.1.S1_at (Zebrafish Array)   NM_001007404_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000047019
NCBI entrez gene - 492763     See in Manteia.
RefSeq - NM_001007404
RefSeq Peptide - NP_001007405
swissprot - F1QSB1
ZFIN ID - ZDB-GENE-030825-5
Ensembl - ENSDARG00000004325
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CASP9ENSGALG00000001366Gallus gallus
 CASP9ENSG00000132906Homo sapiens
 Casp9ENSMUSG00000028914Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
casp7 / caspase 7, apoptosis-related cysteine peptidase / P97864* / P55210* / caspase 7* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*ENSDARG0000009183624
casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2 / CASP10* / Q92851* / caspase 10*ENSDARG0000007027223
casp2 / caspase 2, apoptosis-related cysteine peptidase / P42575* / P29594* / caspase 2* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*ENSDARG0000006205223
si:dkey-103e21.5ENSDARG0000009192622
casp8 / caspase 8, apoptosis-related cysteine peptidase / Q14790* / O89110* / caspase 8* / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10*ENSDARG0000005832522
casp6 / caspase 6, apoptosis-related cysteine peptidase / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000009340521
zgc:194469ENSDARG0000010436721
casp3a / caspase 3, apoptosis-related cysteine peptidase a / CASP3* / P70677* / P42574* / caspase 3* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSDARG0000001790520
casp3b / caspase 3, apoptosis-related cysteine peptidase b / CASP3* / P70677* / P42574* / caspase 3* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSDARG0000005504519
casp6l1 / caspase 6, apoptosis-related cysteine peptidase, like 1 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000002560819
FO834888.1ENSDARG0000005555019
casp6l2 / caspase 6, apoptosis-related cysteine peptidase, like 2 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000007036819
CU467905.1ENSDARG0000011257517
CR925773.1ENSDARG0000008626614


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001315  CARD domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site
 IPR033171  Caspase-9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0048696 regulation of collateral sprouting in absence of injury IMP
 biological_processGO:0097194 execution phase of apoptosis IBA
 biological_processGO:0097205 renal filtration IMP
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
NOD1/2 Signaling Pathway
AKT phosphorylates targets in the cytosol
via Dependence Receptors in the absence of ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000112 gut gut edematous , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon has extra parts of type retinal ganglion cell presynaptic active zone, abnormal
retinal ganglion cell axon increased branchiness , abnormal
retinal ganglion cell axon collateral increased length , abnormal
retinal ganglion cell collateral sprouting in absence of injury increased occurrence , abnormal
retinal ganglion cell cysteine-type endopeptidase activity decreased occurrence , abnormal
retinal ganglion cell neuron remodeling decreased process quality , abnormal
retinal ganglion cell axon physical object quality , abnormal
retinal ganglion cell axon collateral physical object quality , abnormal
retinal ganglion cell collateral sprouting in absence of injury occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004325 casp9 / caspase 9, apoptosis-related cysteine peptidase / P55211* / Q8C3Q9* / caspase 9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*  / complex
 ENSDARG00000021239 apaf1 / apoptotic peptidase activating factor 1 / O14727* / O88879* / Apoptotic protease-activating factor 1 *  / reaction / complex






 

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