ENSDARG00000017905


Danio rerio

Features
Gene ID: ENSDARG00000017905
  
Biological name :casp3a
  
Synonyms : casp3a / caspase 3, apoptosis-related cysteine peptidase a
  
Possible biological names infered from orthology : CASP3 / caspase 3 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574 / P70677
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 17527342
Gene end: 17536307
  
Corresponding Affymetrix probe sets: Dr.11726.1.S1_at (Zebrafish Array)   Dr.4796.1.A1_at (Zebrafish Array)   NM_131877_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000006831
Ensembl peptide - ENSDARP00000117716
Ensembl peptide - ENSDARP00000115915
Ensembl peptide - ENSDARP00000114795
NCBI entrez gene - 140621     See in Manteia.
RefSeq - NM_131877
RefSeq Peptide - NP_571952
swissprot - B8JK20
swissprot - E9QIX2
swissprot - F1QDH1
swissprot - B8JK21
ZFIN ID - ZDB-GENE-011210-1
Ensembl - ENSDARG00000017905
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CASP3ENSGALG00000010638Gallus gallus
 CASP3ENSG00000164305Homo sapiens
 Casp3ENSMUSG00000031628Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
casp3b / caspase 3, apoptosis-related cysteine peptidase b / CASP3* / P70677* / P42574* / caspase 3* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSDARG0000005504558
casp7 / caspase 7, apoptosis-related cysteine peptidase / P97864* / P55210* / caspase 7* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*ENSDARG0000009183653
FO834888.1ENSDARG0000005555039
casp6 / caspase 6, apoptosis-related cysteine peptidase / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000009340536
casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2 / CASP10* / Q92851* / caspase 10*ENSDARG0000007027234
casp6l1 / caspase 6, apoptosis-related cysteine peptidase, like 1 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000002560833
si:dkey-103e21.5ENSDARG0000009192633
casp8 / caspase 8, apoptosis-related cysteine peptidase / Q14790* / O89110* / caspase 8* / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10*ENSDARG0000005832532
casp6l2 / caspase 6, apoptosis-related cysteine peptidase, like 2 / CASP6* / P55212* / O08738* / caspase 6* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSDARG0000007036832
casp9 / caspase 9, apoptosis-related cysteine peptidase / P55211* / Q8C3Q9* / caspase 9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*ENSDARG0000000432531
zgc:194469ENSDARG0000010436730
CU467905.1ENSDARG0000011257528
casp2 / caspase 2, apoptosis-related cysteine peptidase / P42575* / P29594* / caspase 2* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*ENSDARG0000006205226
CR925773.1ENSDARG0000008626623


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0030216 keratinocyte differentiation IBA
 biological_processGO:0030218 erythrocyte differentiation IBA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0048696 regulation of collateral sprouting in absence of injury IMP
 biological_processGO:0071236 cellular response to antibiotic IDA
 biological_processGO:0071300 cellular response to retinoic acid IDA
 biological_processGO:0071466 cellular response to xenobiotic stimulus IDA
 biological_processGO:0097194 execution phase of apoptosis IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IMP
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Activation of caspases through apoptosome-mediated cleavage
Apoptotic cleavage of cellular proteins
Signaling by Hippo
Activation of DNA fragmentation factor
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
via Dependence Receptors in the absence of ligand
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000445 optic tectum optic tectum microglial cell decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell neuron remodeling decreased process quality , abnormal
retinal ganglion cell axon collateral physical object quality , abnormal
retinal ganglion cell collateral sprouting in absence of injury occurrence , abnormal
retinal ganglion cell axon has extra parts of type retinal ganglion cell presynaptic active zone, abnormal
retinal ganglion cell axon increased branchiness , abnormal
retinal ganglion cell axon collateral increased length , abnormal
retinal ganglion cell collateral sprouting in absence of injury increased occurrence , abnormal
retinal ganglion cell cysteine-type endopeptidase activity decreased occurrence , abnormal
retinal ganglion cell axon physical object quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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