ENSGALG00000012692


Gallus gallus

Features
Gene ID: ENSGALG00000012692
  
Biological name :SIRT5
  
Synonyms : E1BRE2 / NAD-dependent protein deacylase sirtuin-5, mitochondrial / SIRT5
  
Possible biological names infered from orthology : Q8K2C6 / Q9NXA8 / sirtuin 5
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 60712567
Gene end: 60720029
  
Corresponding Affymetrix probe sets: Gga.12456.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020691
NCBI entrez gene - 420834     See in Manteia.
RefSeq - XM_015275873
RefSeq - NM_001276364
RefSeq - XM_015275872
RefSeq Peptide - NP_001263293
swissprot - R9PXP3
swissprot - E1BRE2
Ensembl - ENSGALG00000012692
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt5ENSDARG00000039684Danio rerio
 SIRT5ENSG00000124523Homo sapiens
 Sirt5ENSMUSG00000054021Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT4 / sirtuin 4 / Q8R216* / Q9Y6E7* / NAD-dependent protein lipoamidase sirtuin-4, mitochondrial *ENSGALG0000000724425
SIRT1 / NAD-dependent protein deacetylase sirtuin-1 / Q923E4* / Q96EB6* / sirtuin 1* / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment*ENSGALG0000000276123


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026590  Sirtuin family, catalytic core domain
 IPR026591  Sirtuin, catalytic core small domain superfamily
 IPR027546  Sirtuin, class III
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0010566 regulation of ketone biosynthetic process IEA
 biological_processGO:0036046 protein demalonylation IEA
 biological_processGO:0036047 peptidyl-lysine demalonylation IEA
 biological_processGO:0036048 protein desuccinylation IEA
 biological_processGO:0036049 peptidyl-lysine desuccinylation IEA
 biological_processGO:0061698 protein deglutarylation IEA
 biological_processGO:0061699 peptidyl-lysine deglutarylation IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol ISS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity IEA
 molecular_functionGO:0036054 protein-malonyllysine demalonylase activity ISS
 molecular_functionGO:0036055 protein-succinyllysine desuccinylase activity ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061697 protein-glutaryllysine deglutarylase activity IEA
 molecular_functionGO:0070403 NAD+ binding ISS


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011020 CYCS / P67881 / Cytochrome c / P99999* / P62897* / Gm10053* / predicted gene 10053* / cytochrome c, somatic*  / reaction






 

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