ENSG00000101945


Homo sapiens

Features
Gene ID: ENSG00000101945
  
Biological name :SUV39H1
  
Synonyms : O43463 / suppressor of variegation 3-9 homolog 1 / SUV39H1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p11.23
Gene start: 48695554
Gene end: 48709012
  
Corresponding Affymetrix probe sets: 218619_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000337976
Ensembl peptide - ENSP00000365877
NCBI entrez gene - 6839     See in Manteia.
OMIM - 300254
RefSeq - NM_001282166
RefSeq - NM_003173
RefSeq Peptide - NP_001269095
RefSeq Peptide - NP_003164
swissprot - O43463
Ensembl - ENSG00000101945
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6DGD3ENSDARG00000026799Danio rerio
 suv39h1bENSDARG00000055753Danio rerio
 O54864ENSMUSG00000039231Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H5I1 / SUV39H2 / suppressor of variegation 3-9 homolog 2ENSG0000015245557
SETD2 / Q9BYW2 / SET domain containing 2ENSG0000018155528
EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2ENSG0000020437126
EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1ENSG0000018109026
Q15047 / SETDB1 / SET domain bifurcated 1ENSG0000014337925
ASH1L / Q9NR48 / ASH1 like histone lysine methyltransferaseENSG0000011653924
NSD1 / Q96L73 / nuclear receptor binding SET domain protein 1ENSG0000016567123
NSD3 / Q9BZ95 / nuclear receptor binding SET domain protein 3ENSG0000014754821
Q53H47 / SETMAR / SET domain and mariner transposase fusion geneENSG0000017036421
EZH1 / Q92800 / enhancer of zeste 1 polycomb repressive complex 2 subunitENSG0000010879921
EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunitENSG0000010646220
NSD2 / O96028 / nuclear receptor binding SET domain protein 2ENSG0000010968520
Q96T68 / SETDB2 / SET domain bifurcated 2ENSG0000013616920
Q9Y6X0 / SETBP1 / SET binding protein 1ENSG0000015221713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR001214  SET domain
 IPR003616  Post-SET domain
 IPR007728  Pre-SET domain
 IPR011381  Histone H3-K9 methyltransferase
 IPR016197  Chromo-like domain superfamily
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006325 chromatin organization TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0036123 histone H3-K9 dimethylation ISS
 biological_processGO:0036124 histone H3-K9 trimethylation ISS
 biological_processGO:0042754 negative regulation of circadian rhythm ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0071456 cellular response to hypoxia IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0000794 condensed nuclear chromosome TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005652 nuclear lamina IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005677 chromatin silencing complex IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0033553 rDNA heterochromatin IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding ISS
 molecular_functionGO:0003682 chromatin binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity TAS
 molecular_functionGO:0042054 histone methyltransferase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046974 histone methyltransferase activity (H3-K9 specific) EXP
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
SIRT1 negatively regulates rRNA expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000096717 SIRT1 / Q96EB6 / sirtuin 1  / complex / reaction
 ENSG00000132275 RRP8 / O43159 / ribosomal RNA processing 8  / complex / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex






 

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