ENSG00000108799


Homo sapiens

Features
Gene ID: ENSG00000108799
  
Biological name :EZH1
  
Synonyms : enhancer of zeste 1 polycomb repressive complex 2 subunit / EZH1 / Q92800
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.2
Gene start: 42700275
Gene end: 42745049
  
Corresponding Affymetrix probe sets: 203249_at (Human Genome U133 Plus 2.0 Array)   211310_at (Human Genome U133 Plus 2.0 Array)   239197_s_at (Human Genome U133 Plus 2.0 Array)   239198_at (Human Genome U133 Plus 2.0 Array)   32259_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467871
Ensembl peptide - ENSP00000467320
Ensembl peptide - ENSP00000468640
Ensembl peptide - ENSP00000404658
Ensembl peptide - ENSP00000407869
Ensembl peptide - ENSP00000464753
Ensembl peptide - ENSP00000465220
Ensembl peptide - ENSP00000465327
Ensembl peptide - ENSP00000465423
Ensembl peptide - ENSP00000465482
Ensembl peptide - ENSP00000466393
Ensembl peptide - ENSP00000466924
Ensembl peptide - ENSP00000467036
NCBI entrez gene - 2145     See in Manteia.
OMIM - 601674
RefSeq - XM_017024352
RefSeq - NM_001321079
RefSeq - NM_001321081
RefSeq - NM_001321082
RefSeq - NM_001991
RefSeq - XM_005257145
RefSeq - XM_011524517
RefSeq - XM_017024350
RefSeq - XM_017024351
RefSeq Peptide - NP_001308008
RefSeq Peptide - NP_001308010
RefSeq Peptide - NP_001982
RefSeq Peptide - NP_001308011
swissprot - K7EJU6
swissprot - K7EK26
swissprot - K7EK66
swissprot - K7EM79
swissprot - K7ENP2
swissprot - K7EPC0
swissprot - K7ESB9
swissprot - Q92800
swissprot - A0A0A0MSY9
swissprot - K7EIH5
Ensembl - ENSG00000108799
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EZH1ENSGALG00000003068Gallus gallus
 Ezh1ENSMUSG00000006920Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunitENSG0000010646265
NSD1 / Q96L73 / nuclear receptor binding SET domain protein 1ENSG0000016567118
EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1ENSG0000018109017
EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2ENSG0000020437116
NSD2 / O96028 / nuclear receptor binding SET domain protein 2ENSG0000010968516
NSD3 / Q9BZ95 / nuclear receptor binding SET domain protein 3ENSG0000014754816
ASH1L / Q9NR48 / ASH1 like histone lysine methyltransferaseENSG0000011653916
Q15047 / SETDB1 / SET domain bifurcated 1ENSG0000014337914
SETD2 / Q9BYW2 / SET domain containing 2ENSG0000018155513
Q9H5I1 / SUV39H2 / suppressor of variegation 3-9 homolog 2ENSG0000015245512
O43463 / SUV39H1 / suppressor of variegation 3-9 homolog 1ENSG0000010194512
Q9Y6X0 / SETBP1 / SET binding protein 1ENSG0000015221711
Q96T68 / SETDB2 / SET domain bifurcated 2ENSG0000013616910
Q53H47 / SETMAR / SET domain and mariner transposase fusion geneENSG000001703648


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR001214  SET domain
 IPR021654  Histone-lysine N-methyltransferase EZH1/EZH2
 IPR026489  CXC domain
 IPR032926  Histone-lysine N-methyltransferase EZH1
 IPR033467  Tesmin/TSO1-like CXC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0070734 histone H3-K27 methylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003682 chromatin binding TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr