ENSG00000143379


Homo sapiens

Features
Gene ID: ENSG00000143379
  
Biological name :SETDB1
  
Synonyms : Q15047 / SETDB1 / SET domain bifurcated 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q21.3
Gene start: 150926263
Gene end: 150964744
  
Corresponding Affymetrix probe sets: 203155_at (Human Genome U133 Plus 2.0 Array)   214197_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357960
Ensembl peptide - ENSP00000357965
Ensembl peptide - ENSP00000436148
Ensembl peptide - ENSP00000435922
Ensembl peptide - ENSP00000432348
Ensembl peptide - ENSP00000409379
Ensembl peptide - ENSP00000407831
Ensembl peptide - ENSP00000271640
Ensembl peptide - ENSP00000357958
Ensembl peptide - ENSP00000357959
NCBI entrez gene - 9869     See in Manteia.
OMIM - 604396
RefSeq - NM_012432
RefSeq - XM_017002955
RefSeq - XM_017002954
RefSeq - XM_017002953
RefSeq - XM_005245641
RefSeq - NM_001145415
RefSeq - NM_001243491
RefSeq Peptide - NP_001230420
RefSeq Peptide - NP_001138887
RefSeq Peptide - NP_036564
swissprot - E9PRF4
swissprot - Q15047
swissprot - X6R732
swissprot - X6RHV1
swissprot - B0QZE6
swissprot - E9PAP1
swissprot - E9PQM8
swissprot - E9PS59
Ensembl - ENSG00000143379
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setdb1bENSDARG00000099021Danio rerio
 SETDB1ENSGALG00000024051Gallus gallus
 Setdb1ENSMUSG00000015697Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96T68 / SETDB2 / SET domain bifurcated 2ENSG0000013616915
EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1ENSG0000018109013
NSD1 / Q96L73 / nuclear receptor binding SET domain protein 1ENSG0000016567112
EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2ENSG0000020437111
NSD2 / O96028 / nuclear receptor binding SET domain protein 2ENSG0000010968511
SETD2 / Q9BYW2 / SET domain containing 2ENSG0000018155510
ASH1L / Q9NR48 / ASH1 like histone lysine methyltransferaseENSG0000011653910
NSD3 / Q9BZ95 / nuclear receptor binding SET domain protein 3ENSG0000014754810
Q9H5I1 / SUV39H2 / suppressor of variegation 3-9 homolog 2ENSG000001524558
EZH1 / Q92800 / enhancer of zeste 1 polycomb repressive complex 2 subunitENSG000001087998
O43463 / SUV39H1 / suppressor of variegation 3-9 homolog 1ENSG000001019458
EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunitENSG000001064628
Q9Y6X0 / SETBP1 / SET binding protein 1ENSG000001522177
Q53H47 / SETMAR / SET domain and mariner transposase fusion geneENSG000001703646


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR001739  Methyl-CpG DNA binding
 IPR002999  Tudor domain
 IPR003616  Post-SET domain
 IPR007728  Pre-SET domain
 IPR016177  DNA-binding domain superfamily
 IPR025796  Histone-lysine N-methyltransferase SETDB1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007265 Ras protein signal transduction IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0033273 response to vitamin IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0090309 positive regulation of methylation-dependent chromatin silencing IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000171681 ATF7IP / Q6VMQ6 / activating transcription factor 7 interacting protein  / complex / reaction






 

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