ENSG00000136169


Homo sapiens

Features
Gene ID: ENSG00000136169
  
Biological name :SETDB2
  
Synonyms : Q96T68 / SETDB2 / SET domain bifurcated 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q14.2
Gene start: 49444374
Gene end: 49495003
  
Corresponding Affymetrix probe sets: 1564970_at (Human Genome U133 Plus 2.0 Array)   1564972_x_at (Human Genome U133 Plus 2.0 Array)   235338_s_at (Human Genome U133 Plus 2.0 Array)   235339_at (Human Genome U133 Plus 2.0 Array)   238684_at (Human Genome U133 Plus 2.0 Array)   238731_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482240
Ensembl peptide - ENSP00000258672
Ensembl peptide - ENSP00000326477
Ensembl peptide - ENSP00000346175
NCBI entrez gene - 83852     See in Manteia.
OMIM - 607865
RefSeq - NM_001160308
RefSeq - NM_001320699
RefSeq - NM_031915
RefSeq Peptide - NP_001153780
RefSeq Peptide - NP_001307628
RefSeq Peptide - NP_114121
swissprot - X6R383
swissprot - A0A087WYZ9
swissprot - Q96T68
Ensembl - ENSG00000136169
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SETDB2ENSGALG00000017006Gallus gallus
 Q8C267ENSMUSG00000071350Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q15047 / SETDB1 / SET domain bifurcated 1ENSG0000014337926
EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1ENSG0000018109017
EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2ENSG0000020437116
NSD1 / Q96L73 / nuclear receptor binding SET domain protein 1ENSG0000016567114
Q9H5I1 / SUV39H2 / suppressor of variegation 3-9 homolog 2ENSG0000015245513
SETD2 / Q9BYW2 / SET domain containing 2ENSG0000018155513
O43463 / SUV39H1 / suppressor of variegation 3-9 homolog 1ENSG0000010194512
NSD3 / Q9BZ95 / nuclear receptor binding SET domain protein 3ENSG0000014754812
NSD2 / O96028 / nuclear receptor binding SET domain protein 2ENSG0000010968512
EZH1 / Q92800 / enhancer of zeste 1 polycomb repressive complex 2 subunitENSG0000010879911
Q9Y6X0 / SETBP1 / SET binding protein 1ENSG0000015221711
Q53H47 / SETMAR / SET domain and mariner transposase fusion geneENSG0000017036411
EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunitENSG0000010646210
ASH1L / Q9NR48 / ASH1 like histone lysine methyltransferaseENSG000001165399


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR001739  Methyl-CpG DNA binding
 IPR007728  Pre-SET domain
 IPR016177  DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0001947 heart looping ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051567 histone H3-K9 methylation IDA
 biological_processGO:0070986 left/right axis specification ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046974 histone methyltransferase activity (H3-K9 specific) IDA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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