ENSG00000147548


Homo sapiens

Features
Gene ID: ENSG00000147548
  
Biological name :NSD3
  
Synonyms : NSD3 / nuclear receptor binding SET domain protein 3 / Q9BZ95
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p11.23
Gene start: 38269697
Gene end: 38382272
  
Corresponding Affymetrix probe sets: 218173_s_at (Human Genome U133 Plus 2.0 Array)   221248_s_at (Human Genome U133 Plus 2.0 Array)   222544_s_at (Human Genome U133 Plus 2.0 Array)   224076_s_at (Human Genome U133 Plus 2.0 Array)   224077_at (Human Genome U133 Plus 2.0 Array)   225318_at (Human Genome U133 Plus 2.0 Array)   238496_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431598
Ensembl peptide - ENSP00000435422
Ensembl peptide - ENSP00000435073
Ensembl peptide - ENSP00000434730
Ensembl peptide - ENSP00000432544
Ensembl peptide - ENSP00000313410
Ensembl peptide - ENSP00000313983
Ensembl peptide - ENSP00000393284
NCBI entrez gene - 54904     See in Manteia.
OMIM - 607083
RefSeq - NM_017778
RefSeq - NM_023034
RefSeq Peptide - NP_060248
RefSeq Peptide - NP_075447
swissprot - Q9BZ95
swissprot - E9PKL3
swissprot - E9PKA2
swissprot - H0YE68
swissprot - E9PQ95
Ensembl - ENSG00000147548
  
Related genetic diseases (OMIM): 601626 - Leukemia, acute myeloid, 601626
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nsd3ENSDARG00000062765Danio rerio
 NSD3ENSGALG00000003299Gallus gallus
 Nsd3ENSMUSG00000054823Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NSD2 / O96028 / nuclear receptor binding SET domain protein 2ENSG0000010968543
NSD1 / Q96L73 / nuclear receptor binding SET domain protein 1ENSG0000016567142
SETD2 / Q9BYW2 / SET domain containing 2ENSG0000018155516
ASH1L / Q9NR48 / ASH1 like histone lysine methyltransferaseENSG0000011653915
EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1ENSG0000018109013
EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2ENSG0000020437110
EZH1 / Q92800 / enhancer of zeste 1 polycomb repressive complex 2 subunitENSG000001087999
Q15047 / SETDB1 / SET domain bifurcated 1ENSG000001433799
Q9Y6X0 / SETBP1 / SET binding protein 1ENSG000001522179
EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunitENSG000001064628
O43463 / SUV39H1 / suppressor of variegation 3-9 homolog 1ENSG000001019456
Q9H5I1 / SUV39H2 / suppressor of variegation 3-9 homolog 2ENSG000001524556
Q96T68 / SETDB2 / SET domain bifurcated 2ENSG000001361696
Q53H47 / SETMAR / SET domain and mariner transposase fusion geneENSG000001703645


Protein motifs (from Interpro)
Interpro ID Name
 IPR000313  PWWP domain
 IPR001214  SET domain
 IPR001965  Zinc finger, PHD-type
 IPR003616  Post-SET domain
 IPR006560  AWS domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016571 histone methylation IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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