ENSMUSG00000054823


Mus musculus

Features
Gene ID: ENSMUSG00000054823
  
Biological name :Nsd3
  
Synonyms : Histone-lysine N-methyltransferase NSD3 / Nsd3 / Q6P2L6
  
Possible biological names infered from orthology : nuclear receptor binding SET domain protein 3 / Q9BZ95
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 25601601
Gene end: 25719667
  
Corresponding Affymetrix probe sets: 10571007 (MoGene1.0st)   1442085_at (Mouse Genome 430 2.0 Array)   1447931_at (Mouse Genome 430 2.0 Array)   1455668_at (Mouse Genome 430 2.0 Array)   1457793_a_at (Mouse Genome 430 2.0 Array)   1457794_at (Mouse Genome 430 2.0 Array)   1459907_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122096
Ensembl peptide - ENSMUSP00000117778
Ensembl peptide - ENSMUSP00000123028
Ensembl peptide - ENSMUSP00000147926
Ensembl peptide - ENSMUSP00000147840
Ensembl peptide - ENSMUSP00000081040
Ensembl peptide - ENSMUSP00000115470
Ensembl peptide - ENSMUSP00000117596
NCBI entrez gene - 234135     See in Manteia.
MGI - MGI:2142581
RefSeq - XM_017312681
RefSeq - NM_001001735
RefSeq - NM_001081269
RefSeq - NM_001308481
RefSeq - NM_001308482
RefSeq - XM_017312676
RefSeq - XM_017312677
RefSeq - XM_017312678
RefSeq - XM_017312679
RefSeq - XM_017312680
RefSeq Peptide - NP_001074738
RefSeq Peptide - NP_001295410
RefSeq Peptide - NP_001295411
RefSeq Peptide - NP_001001735
swissprot - D3Z357
swissprot - Q6P2L6
swissprot - D3Z197
swissprot - D3YUP2
swissprot - A0A1B0GSG3
Ensembl - ENSMUSG00000054823
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nsd3ENSDARG00000062765Danio rerio
 NSD3ENSGALG00000003299Gallus gallus
 NSD3ENSG00000147548Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*ENSMUSG0000005740643
Nsd1 / nuclear receptor-binding SET-domain protein 1 / Q96L73*ENSMUSG0000002148840
Setd2 / E9Q5F9 / Histone-lysine N-methyltransferase SETD2 / Q9BYW2* / SET domain containing 2*ENSMUSG0000004479116
Ash1l / Q99MY8 / Histone-lysine N-methyltransferase ASH1L / Q9NR48* / ASH1 like histone lysine methyltransferase*ENSMUSG0000002805315
Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSMUSG0000003689312
Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*ENSMUSG0000001378710
Setdb1 / SET domain, bifurcated 1 / Q15047*ENSMUSG000000156979
Q9Z180 / Setbp1 / SET-binding protein / Q9Y6X0* / SET binding protein 1*ENSMUSG000000245489
Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*ENSMUSG000000296878
Ezh1 / P70351 / Histone-lysine N-methyltransferase EZH1 / Q92800* / enhancer of zeste 1 polycomb repressive complex 2 subunit*ENSMUSG000000069208
Q8C267 / Setdb2 / SET domain, bifurcated 2 / Q96T68*ENSMUSG000000713506
Suv39h2 / suppressor of variegation 3-9 2 / Q9H5I1* / suppressor of variegation 3-9 homolog 2*ENSMUSG000000266466
O54864 / Suv39h1 / suppressor of variegation 3-9 1 / O43463* / suppressor of variegation 3-9 homolog 1*ENSMUSG000000392316
Q80UJ9 / Setmar / Histone-lysine N-methyltransferase SETMAR / Q53H47* / SET domain and mariner transposase fusion gene*ENSMUSG000000346395


Protein motifs (from Interpro)
Interpro ID Name
 IPR000313  PWWP domain
 IPR001214  SET domain
 IPR001965  Zinc finger, PHD-type
 IPR003616  Post-SET domain
 IPR006560  AWS domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016571 histone methylation ISO
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0051568 histone H3-K4 methylation IEA
 biological_processGO:0070734 histone H3-K27 methylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046976 histone methyltransferase activity (H3-K27 specific) IDA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0003795 abnormal bone structure 
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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