ENSMUSG00000021488


Mus musculus

Features
Gene ID: ENSMUSG00000021488
  
Biological name :Nsd1
  
Synonyms : Nsd1 / nuclear receptor-binding SET-domain protein 1
  
Possible biological names infered from orthology : Q96L73
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 55209782
Gene end: 55318325
  
Corresponding Affymetrix probe sets: 10405400 (MoGene1.0st)   1420881_at (Mouse Genome 430 2.0 Array)   1435088_at (Mouse Genome 430 2.0 Array)   1440972_at (Mouse Genome 430 2.0 Array)   1456916_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153366
Ensembl peptide - ENSMUSP00000152939
Ensembl peptide - ENSMUSP00000153503
Ensembl peptide - ENSMUSP00000153677
Ensembl peptide - ENSMUSP00000153511
Ensembl peptide - ENSMUSP00000097089
NCBI entrez gene - 18193     See in Manteia.
MGI - MGI:1276545
RefSeq - XM_011244496
RefSeq - XM_006517144
RefSeq - XM_006517145
RefSeq - XM_006517146
RefSeq - XM_006517147
RefSeq - XM_006517148
RefSeq - NM_008739
RefSeq - XM_006517134
RefSeq - XM_006517135
RefSeq - XM_006517136
RefSeq - XM_006517137
RefSeq - XM_006517138
RefSeq - XM_006517140
RefSeq - XM_006517141
RefSeq - XM_006517142
RefSeq - XM_006517143
RefSeq Peptide - NP_032765
swissprot - E9QAE4
swissprot - A0A286YE36
swissprot - A0A286YDS9
swissprot - A0A286YDN7
Ensembl - ENSMUSG00000021488
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nsd1aENSDARG00000060016Danio rerio
 nsd1bENSDARG00000060705Danio rerio
 NSD1ENSGALG00000002971Gallus gallus
 NSD1ENSG00000165671Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*ENSMUSG0000005740623
Nsd3 / Q6P2L6 / Histone-lysine N-methyltransferase NSD3 / Q9BZ95* / nuclear receptor binding SET domain protein 3*ENSMUSG0000005482322
Ash1l / Q99MY8 / Histone-lysine N-methyltransferase ASH1L / Q9NR48* / ASH1 like histone lysine methyltransferase*ENSMUSG0000002805312
Setd2 / E9Q5F9 / Histone-lysine N-methyltransferase SETD2 / Q9BYW2* / SET domain containing 2*ENSMUSG0000004479110
Q9Z180 / Setbp1 / SET-binding protein / Q9Y6X0* / SET binding protein 1*ENSMUSG000000245487
Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*ENSMUSG000000137877
Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSMUSG000000368937
Ezh1 / P70351 / Histone-lysine N-methyltransferase EZH1 / Q92800* / enhancer of zeste 1 polycomb repressive complex 2 subunit*ENSMUSG000000069205
Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*ENSMUSG000000296875
Setdb1 / SET domain, bifurcated 1 / Q15047*ENSMUSG000000156975
Suv39h2 / suppressor of variegation 3-9 2 / Q9H5I1* / suppressor of variegation 3-9 homolog 2*ENSMUSG000000266464
O54864 / Suv39h1 / suppressor of variegation 3-9 1 / O43463* / suppressor of variegation 3-9 homolog 1*ENSMUSG000000392314
Q80UJ9 / Setmar / Histone-lysine N-methyltransferase SETMAR / Q53H47* / SET domain and mariner transposase fusion gene*ENSMUSG000000346393
Q8C267 / Setdb2 / SET domain, bifurcated 2 / Q96T68*ENSMUSG000000713503


Protein motifs (from Interpro)
Interpro ID Name
 IPR000313  PWWP domain
 IPR001214  SET domain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003616  Post-SET domain
 IPR006560  AWS domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000414 regulation of histone H3-K36 methylation IEA
 biological_processGO:0010452 histone H3-K36 methylation IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0033135 regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046975 histone methyltransferase activity (H3-K36 specific) IEA
 molecular_functionGO:0050681 androgen receptor binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002174 abnormal gastrulation movements "failure of embryonic cells to migrate, or migrate to the appropriate target during the development and invagination of the primary germ layers" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:52418]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009266 abnormal mesendoderm development "failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009331 absent primitive node "absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr