ENSMUSG00000028053


Mus musculus

Features
Gene ID: ENSMUSG00000028053
  
Biological name :Ash1l
  
Synonyms : Ash1l / Histone-lysine N-methyltransferase ASH1L / Q99MY8
  
Possible biological names infered from orthology : ASH1 like histone lysine methyltransferase / Q9NR48
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 88950622
Gene end: 89079375
  
Corresponding Affymetrix probe sets: 10493347 (MoGene1.0st)   1420985_at (Mouse Genome 430 2.0 Array)   1450071_at (Mouse Genome 430 2.0 Array)   1450072_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000088451
Ensembl peptide - ENSMUSP00000140251
NCBI entrez gene - 192195     See in Manteia.
MGI - MGI:2183158
RefSeq - XM_017319502
RefSeq - NM_138679
RefSeq - XM_006501141
RefSeq - XM_006501142
RefSeq Peptide - NP_619620
swissprot - Q99MY8
Ensembl - ENSMUSG00000028053
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ash1lENSDARG00000070981Danio rerio
 ASH1LENSGALG00000014638Gallus gallus
 ASH1LENSG00000116539Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Setd2 / E9Q5F9 / Histone-lysine N-methyltransferase SETD2 / Q9BYW2* / SET domain containing 2*ENSMUSG0000004479114
Nsd1 / nuclear receptor-binding SET-domain protein 1 / Q96L73*ENSMUSG0000002148811
Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*ENSMUSG000000574068
Nsd3 / Q6P2L6 / Histone-lysine N-methyltransferase NSD3 / Q9BZ95* / nuclear receptor binding SET domain protein 3*ENSMUSG000000548237
Q9Z180 / Setbp1 / SET-binding protein / Q9Y6X0* / SET binding protein 1*ENSMUSG000000245486
Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*ENSMUSG000000137875
Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSMUSG000000368935
Setdb1 / SET domain, bifurcated 1 / Q15047*ENSMUSG000000156975
Suv39h2 / suppressor of variegation 3-9 2 / Q9H5I1* / suppressor of variegation 3-9 homolog 2*ENSMUSG000000266464
Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*ENSMUSG000000296874
Ezh1 / P70351 / Histone-lysine N-methyltransferase EZH1 / Q92800* / enhancer of zeste 1 polycomb repressive complex 2 subunit*ENSMUSG000000069204
O54864 / Suv39h1 / suppressor of variegation 3-9 1 / O43463* / suppressor of variegation 3-9 homolog 1*ENSMUSG000000392313
Q80UJ9 / Setmar / Histone-lysine N-methyltransferase SETMAR / Q53H47* / SET domain and mariner transposase fusion gene*ENSMUSG000000346393
Q8C267 / Setdb2 / SET domain, bifurcated 2 / Q96T68*ENSMUSG000000713502


Protein motifs (from Interpro)
Interpro ID Name
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR001214  SET domain
 IPR001487  Bromodomain
 IPR001965  Zinc finger, PHD-type
 IPR003616  Post-SET domain
 IPR006560  AWS domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017956  AT hook, DNA-binding motif
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0002674 negative regulation of acute inflammatory response IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007338 single fertilization IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032635 interleukin-6 production IGI
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043409 negative regulation of MAPK cascade IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046697 decidualization IMP
 biological_processGO:0048733 sebaceous gland development IMP
 biological_processGO:0050728 negative regulation of inflammatory response IGI
 biological_processGO:0051568 histone H3-K4 methylation IDA
 biological_processGO:0061038 uterus morphogenesis IMP
 biological_processGO:0097676 histone H3-K36 dimethylation ISO
 biological_processGO:0097722 sperm motility IMP
 biological_processGO:1903699 tarsal gland development IMP
 biological_processGO:1903709 uterine gland development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046975 histone methyltransferase activity (H3-K36 specific) ISO


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arvcftm1e(EUCOMM)Wtsi/Arvcftm1e(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Arvcftm1e(EUCOMM)Wtsi/Ieg

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu/Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.Cg-Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu Il6tm1Kopf

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002637 small uterus "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002662 abnormal cauda "anomalous structure of the tail of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002769 abnormal vas deferens morphology "malformation of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu/Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu,Il6tm1Kopf/Il6tm1Kopf
Genetic Background: B6.Cg-Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu Il6tm1Kopf

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003845 abnormal decidualization "disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43609, J:48920]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0006236 absent meibomian glands "missing meibomian glands" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0006243 abnormal pupil dilation reaction to light "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Arvcftm1e(EUCOMM)Wtsi/Arvcftm1e(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Arvcftm1e(EUCOMM)Wtsi/Ieg

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008258 thin endometrium "reduced thickness of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0009096 decreased endometrial gland number "fewer than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0009669 abnormal postimplantation uterine environment "failure of the uterus to undergo the changes necessary to support pregnancy following implantation of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010855 pulmonary hyperemia "increased amount of blood flow into the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0013192 decreased sebaceous gland number "fewer than normal numbers of the holocrine glands that secrete sebum into the hair follicles, or in hairless areas into ducts" [MGI:anna]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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