ENSMUSG00000015697


Mus musculus

Features
Gene ID: ENSMUSG00000015697
  
Biological name :Setdb1
  
Synonyms : Setdb1 / SET domain, bifurcated 1
  
Possible biological names infered from orthology : Q15047
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 95323525
Gene end: 95357202
  
Corresponding Affymetrix probe sets: 10500157 (MoGene1.0st)   1416670_at (Mouse Genome 430 2.0 Array)   1451833_a_at (Mouse Genome 430 2.0 Array)   1458215_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102789
Ensembl peptide - ENSMUSP00000015841
Ensembl peptide - ENSMUSP00000102788
NCBI entrez gene - 84505     See in Manteia.
MGI - MGI:1934229
RefSeq - NM_001163642
RefSeq - NM_018877
RefSeq - NM_001163641
RefSeq Peptide - NP_061365
RefSeq Peptide - NP_001157113
RefSeq Peptide - NP_001157114
swissprot - D3YYC3
swissprot - G5E8N3
Ensembl - ENSMUSG00000015697
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setdb1bENSDARG00000099021Danio rerio
 SETDB1ENSGALG00000024051Gallus gallus
 Q15047ENSG00000143379Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C267 / Setdb2 / SET domain, bifurcated 2 / Q96T68*ENSMUSG0000007135014
Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSMUSG0000003689313
Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*ENSMUSG0000001378711
Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*ENSMUSG0000005740611
Nsd1 / nuclear receptor-binding SET-domain protein 1 / Q96L73*ENSMUSG0000002148811
Nsd3 / Q6P2L6 / Histone-lysine N-methyltransferase NSD3 / Q9BZ95* / nuclear receptor binding SET domain protein 3*ENSMUSG0000005482310
Setd2 / E9Q5F9 / Histone-lysine N-methyltransferase SETD2 / Q9BYW2* / SET domain containing 2*ENSMUSG0000004479110
Ash1l / Q99MY8 / Histone-lysine N-methyltransferase ASH1L / Q9NR48* / ASH1 like histone lysine methyltransferase*ENSMUSG0000002805310
Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*ENSMUSG000000296878
O54864 / Suv39h1 / suppressor of variegation 3-9 1 / O43463* / suppressor of variegation 3-9 homolog 1*ENSMUSG000000392318
Suv39h2 / suppressor of variegation 3-9 2 / Q9H5I1* / suppressor of variegation 3-9 homolog 2*ENSMUSG000000266468
Ezh1 / P70351 / Histone-lysine N-methyltransferase EZH1 / Q92800* / enhancer of zeste 1 polycomb repressive complex 2 subunit*ENSMUSG000000069208
Q9Z180 / Setbp1 / SET-binding protein / Q9Y6X0* / SET binding protein 1*ENSMUSG000000245487
Q80UJ9 / Setmar / Histone-lysine N-methyltransferase SETMAR / Q53H47* / SET domain and mariner transposase fusion gene*ENSMUSG000000346396


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR001739  Methyl-CpG DNA binding
 IPR002999  Tudor domain
 IPR003616  Post-SET domain
 IPR007728  Pre-SET domain
 IPR016177  DNA-binding domain superfamily
 IPR025796  Histone-lysine N-methyltransferase SETDB1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0033273 response to vitamin IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0090309 positive regulation of methylation-dependent chromatin silencing IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Emx2tm2(cre)Sia/Emx2+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Slc3a2tm1.1Yait/Slc3a2tm1.1Yait,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc3a2tm1.1Yait/Slc3a2tm1.1Yait,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Tg(Nes-cre)1Kag/0
Genetic Background: Not Specified

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Emx2tm2(cre)Sia/Emx2+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Emx2tm2(cre)Sia/Emx2+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Emx2tm2(cre)Sia/Emx2+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Emx2tm2(cre)Sia/Emx2+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Emx2tm2(cre)Sia/Emx2+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Emx2tm2(cre)Sia/Emx2+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Emx2tm2(cre)Sia/Emx2+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Emx2tm2(cre)Sia/Emx2+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Emx2tm2(cre)Sia/Emx2+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Emx2tm2(cre)Sia/Emx2+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Tg(Nes-cre)1Kag/0
Genetic Background: Not Specified

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012113 decreased inner cell mass proliferation 
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Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030213 Atf7ip / Q7TT18 / Activating transcription factor 7-interacting protein 1 / Q6VMQ6* / activating transcription factor 7 interacting protein*  / complex / reaction






 

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