ENSMUSG00000044791


Mus musculus

Features
Gene ID: ENSMUSG00000044791
  
Biological name :Setd2
  
Synonyms : E9Q5F9 / Histone-lysine N-methyltransferase SETD2 / Setd2
  
Possible biological names infered from orthology : Q9BYW2 / SET domain containing 2
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 110532597
Gene end: 110618633
  
Corresponding Affymetrix probe sets: 10589565 (MoGene1.0st)   10589587 (MoGene1.0st)   1428555_at (Mouse Genome 430 2.0 Array)   1444006_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116313
Ensembl peptide - ENSMUSP00000143774
Ensembl peptide - ENSMUSP00000142960
Ensembl peptide - ENSMUSP00000142933
Ensembl peptide - ENSMUSP00000142572
Ensembl peptide - ENSMUSP00000142553
NCBI entrez gene - 235626     See in Manteia.
MGI - MGI:1918177
RefSeq - XM_011242963
RefSeq - NM_001081340
RefSeq - XM_006512088
RefSeq - XM_006512091
RefSeq - XM_006512092
RefSeq - XM_006512094
RefSeq Peptide - NP_001074809
swissprot - A0A0G2JEZ4
swissprot - E9Q5F9
swissprot - A0A0G2JDZ6
swissprot - A0A0G2JDY1
swissprot - A0A0G2JH06
swissprot - A0A0G2JEW8
Ensembl - ENSMUSG00000044791
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setd2ENSDARG00000062244Danio rerio
 SETD2ENSGALG00000042051Gallus gallus
 SETD2ENSG00000181555Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ash1l / Q99MY8 / Histone-lysine N-methyltransferase ASH1L / Q9NR48* / ASH1 like histone lysine methyltransferase*ENSMUSG0000002805317
Nsd1 / nuclear receptor-binding SET-domain protein 1 / Q96L73*ENSMUSG0000002148811
Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*ENSMUSG000000574069
Nsd3 / Q6P2L6 / Histone-lysine N-methyltransferase NSD3 / Q9BZ95* / nuclear receptor binding SET domain protein 3*ENSMUSG000000548239
Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSMUSG000000368937
Q9Z180 / Setbp1 / SET-binding protein / Q9Y6X0* / SET binding protein 1*ENSMUSG000000245487
Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*ENSMUSG000000137876
Suv39h2 / suppressor of variegation 3-9 2 / Q9H5I1* / suppressor of variegation 3-9 homolog 2*ENSMUSG000000266465
Setdb1 / SET domain, bifurcated 1 / Q15047*ENSMUSG000000156975
O54864 / Suv39h1 / suppressor of variegation 3-9 1 / O43463* / suppressor of variegation 3-9 homolog 1*ENSMUSG000000392315
Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*ENSMUSG000000296874
Ezh1 / P70351 / Histone-lysine N-methyltransferase EZH1 / Q92800* / enhancer of zeste 1 polycomb repressive complex 2 subunit*ENSMUSG000000069204
Q80UJ9 / Setmar / Histone-lysine N-methyltransferase SETMAR / Q53H47* / SET domain and mariner transposase fusion gene*ENSMUSG000000346393
Q8C267 / Setdb2 / SET domain, bifurcated 2 / Q96T68*ENSMUSG000000713503


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain
 IPR001214  SET domain
 IPR003616  Post-SET domain
 IPR006560  AWS domain
 IPR013257  Set2 Rpb1 interacting domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001763 morphogenesis of a branching structure IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010452 histone H3-K36 methylation IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IEA
 biological_processGO:0010793 regulation of mRNA export from nucleus IEA
 biological_processGO:0018023 peptidyl-lysine trimethylation IEA
 biological_processGO:0018026 peptidyl-lysine monomethylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0032727 positive regulation of interferon-alpha production IEA
 biological_processGO:0034340 response to type I interferon IEA
 biological_processGO:0034728 nucleosome organization IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0035441 cell migration involved in vasculogenesis IMP
 biological_processGO:0035987 endodermal cell differentiation IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0048332 mesoderm morphogenesis IMP
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:0048864 stem cell development IMP
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0060039 pericardium development IMP
 biological_processGO:0060669 embryonic placenta morphogenesis IMP
 biological_processGO:0060977 coronary vasculature morphogenesis IMP
 biological_processGO:0097198 histone H3-K36 trimethylation IEA
 biological_processGO:0097676 histone H3-K36 dimethylation IEA
 biological_processGO:1902850 microtubule cytoskeleton organization involved in mitosis IEA
 biological_processGO:1905634 regulation of protein localization to chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0043014 alpha-tubulin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046975 histone methyltransferase activity (H3-K36 specific) IMP


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0003795 abnormal bone structure 
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0003873 branchial arch hypoplasia "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0012176 abnormal head development "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0020516 abnormal visceral yolk sac mesenchyme morphology "any structural anomaly of the portion of the visceral yolk sac that is derived from mesoderm and consists of mesenchyme" [UBERON:0003316]
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Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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