ENSMUSG00000029687


Mus musculus

Features
Gene ID: ENSMUSG00000029687
  
Biological name :Ezh2
  
Synonyms : Ezh2 / Histone-lysine N-methyltransferase EZH2 / Q61188
  
Possible biological names infered from orthology : enhancer of zeste 2 polycomb repressive complex 2 subunit / Q15910
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B2.3
Gene start: 47530139
Gene end: 47595341
  
Corresponding Affymetrix probe sets: 10544501 (MoGene1.0st)   1416544_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128542
Ensembl peptide - ENSMUSP00000126481
Ensembl peptide - ENSMUSP00000133195
Ensembl peptide - ENSMUSP00000144781
Ensembl peptide - ENSMUSP00000144780
Ensembl peptide - ENSMUSP00000080419
Ensembl peptide - ENSMUSP00000090318
Ensembl peptide - ENSMUSP00000110263
Ensembl peptide - ENSMUSP00000110265
Ensembl peptide - ENSMUSP00000118663
NCBI entrez gene - 14056     See in Manteia.
MGI - MGI:107940
RefSeq - XM_006505529
RefSeq - NM_001146689
RefSeq - NM_007971
RefSeq - XM_006505520
RefSeq - XM_006505521
RefSeq - XM_006505523
RefSeq - XM_006505524
RefSeq - XM_006505525
RefSeq - XM_006505526
RefSeq - XM_006505527
RefSeq - XM_006505528
RefSeq Peptide - NP_001140161
RefSeq Peptide - NP_031997
swissprot - D3Z774
swissprot - F6T3Z0
swissprot - F7AQX0
swissprot - Q61188
swissprot - A0A0N4SUQ8
swissprot - Q6AXH7
swissprot - A0A0N4SUQ7
swissprot - F7CW38
swissprot - E9PWK3
Ensembl - ENSMUSG00000029687
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ezh2ENSDARG00000010571Danio rerio
 EZH2ENSGALG00000043399Gallus gallus
 EZH2ENSG00000106462Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ezh1 / P70351 / Histone-lysine N-methyltransferase EZH1 / Q92800* / enhancer of zeste 1 polycomb repressive complex 2 subunit*ENSMUSG0000000692066
Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSMUSG0000003689318
Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*ENSMUSG0000001378717
Nsd1 / nuclear receptor-binding SET-domain protein 1 / Q96L73*ENSMUSG0000002148817
Nsd3 / Q6P2L6 / Histone-lysine N-methyltransferase NSD3 / Q9BZ95* / nuclear receptor binding SET domain protein 3*ENSMUSG0000005482316
Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*ENSMUSG0000005740615
Ash1l / Q99MY8 / Histone-lysine N-methyltransferase ASH1L / Q9NR48* / ASH1 like histone lysine methyltransferase*ENSMUSG0000002805315
Setdb1 / SET domain, bifurcated 1 / Q15047*ENSMUSG0000001569714
Setd2 / E9Q5F9 / Histone-lysine N-methyltransferase SETD2 / Q9BYW2* / SET domain containing 2*ENSMUSG0000004479113
Suv39h2 / suppressor of variegation 3-9 2 / Q9H5I1* / suppressor of variegation 3-9 homolog 2*ENSMUSG0000002664612
O54864 / Suv39h1 / suppressor of variegation 3-9 1 / O43463* / suppressor of variegation 3-9 homolog 1*ENSMUSG0000003923111
Q9Z180 / Setbp1 / SET-binding protein / Q9Y6X0* / SET binding protein 1*ENSMUSG0000002454811
Q8C267 / Setdb2 / SET domain, bifurcated 2 / Q96T68*ENSMUSG0000007135010
Q80UJ9 / Setmar / Histone-lysine N-methyltransferase SETMAR / Q53H47* / SET domain and mariner transposase fusion gene*ENSMUSG000000346398


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR001214  SET domain
 IPR021654  Histone-lysine N-methyltransferase EZH1/EZH2
 IPR026489  CXC domain
 IPR033467  Tesmin/TSO1-like CXC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0006306 DNA methylation IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISO
 biological_processGO:0014013 regulation of gliogenesis IMP
 biological_processGO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IMP
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IDA
 biological_processGO:0016571 histone methylation ISO
 biological_processGO:0021695 cerebellar cortex development IMP
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IMP
 biological_processGO:0035984 cellular response to trichostatin A IMP
 biological_processGO:0036333 hepatocyte homeostasis IGI
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity ISS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IGI
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0045605 negative regulation of epidermal cell differentiation IMP
 biological_processGO:0045814 negative regulation of gene expression, epigenetic ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0051154 negative regulation of striated muscle cell differentiation IDA
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0070314 G1 to G0 transition IMP
 biological_processGO:0070734 histone H3-K27 methylation ISO
 biological_processGO:0071168 protein localization to chromatin IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity ISS
 biological_processGO:0097421 liver regeneration IGI
 biological_processGO:0098532 histone H3-K27 trimethylation IGI
 biological_processGO:1900006 positive regulation of dendrite development IEA
 biological_processGO:1904772 response to tetrachloromethane IGI
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IMP
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 cellular_componentGO:0045120 pronucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001047 core promoter binding IMP
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0003723 RNA binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0031490 chromatin DNA binding ISO
 molecular_functionGO:0042054 histone methyltransferase activity ISO
 molecular_functionGO:0043021 ribonucleoprotein complex binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046976 histone methyltransferase activity (H3-K27 specific) ISO
 molecular_functionGO:0070878 primary miRNA binding IDA
 molecular_functionGO:1990841 promoter-specific chromatin binding ISS


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000380 small hair follicles "reduced size of the invagination of the epidermis from which the hair shaft develops" [J:56777]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

Allelic Composition: Ezh2tm2Sho/Ezh2tm2.1Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

Allelic Composition: Ezh2tm2Sho/Ezh2tm2.1Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

Allelic Composition: Ezh2tm2Sho/Ezh2tm2.1Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tcf4em2Bdph/?
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

Allelic Composition: Ezh2tm1.1Sho/Ezh2tm1.1Sho
Genetic Background: involves: 129 * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Irs1tm1Mfw/Irs1tm1Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

Allelic Composition: Ezh2tm2Sho/Ezh2tm2.1Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GarsNmf249/Gars+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

Allelic Composition: Ezh2tm2.1Sho/Ezh2tm2.1Sho
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: GarsNmf249/Gars+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

Allelic Composition: Ezh2tm2Sho/Ezh2tm2.1Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

Allelic Composition: Ezh2tm2Sho/Ezh2tm2.1Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(CAG-Ezh2*)Meln/Col1a1+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ezh2tm1Tara/Ezh2tm1Tara,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008755 abnormal immunoglobulin V(D)J recombination "any anomaly in the process by which immunoglobulin V, D, and J or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033152, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ezh2tm1Yugo/Ezh2tm1Yugo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Ezh2tm1Yugo/Ezh2tm1Yugo,Tg(Nes-cre/ERT2)5-1Kag/0
Genetic Background: involves: C57BL/6

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0010682 abnormal hair follicle infundibulum morphology "any structural anomaly of the most proximal part of the hair follicle relative to the epidermis, extending from the sebaceous duct to the epidermal surface" [PMID:19211055]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0010684 abnormal hair follicle outer root sheath morphology "any structural anomaly of the outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [PMID:19211055]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: GarsNmf249/Gars+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Ezh2tm1.1Sho/Ezh2tm1.1Sho
Genetic Background: involves: 129 * C57BL/6J

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Ezh2tm2.1Sho/Ezh2tm2.1Sho
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0012114 absent inner cell mass proliferation 
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Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
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Allelic Composition: Ezh2tm2Sho/Ezh2tm2Sho,Olig1tm1(cre)Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004099 Dnmt1 / P13864 / DNA (cytosine-5)-methyltransferase 1 / P26358* / DNA methyltransferase 1*  / complex / reaction
 ENSMUSG00000020661 Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*  / reaction / complex
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / complex / reaction
 ENSMUSG00000024240 Epc1 / Q8C9X6 / Enhancer of polycomb homolog 1 / Q9H2F5*  / complex / reaction
 ENSMUSG00000026873 Phf19 / Q9CXG9 / PHD finger protein 19 / Q5T6S3*  / complex
 ENSMUSG00000030232 Aebp2 / Q9Z248 / Zinc finger protein AEBP2 / Q6ZN18* / AE binding protein 2*  / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / complex
 ENSMUSG00000038518 Jarid2 / Q62315 / Protein Jumonji / Q92833* / jumonji and AT-rich interaction domain containing 2*  / complex
 ENSMUSG00000027478 Dnmt3b / O88509 / DNA (cytosine-5)-methyltransferase 3B / Q9UBC3* / DNA methyltransferase 3 beta*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000024193 Phf1 / Q9Z1B8 / PHD finger protein 1 / O43189*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000029267 Mtf2 / Q02395 / Metal-response element-binding transcription factor 2 / Q9Y483*  / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex / reaction






 

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