ENSMUSG00000038518


Mus musculus

Features
Gene ID: ENSMUSG00000038518
  
Biological name :Jarid2
  
Synonyms : Jarid2 / Protein Jumonji / Q62315
  
Possible biological names infered from orthology : jumonji and AT-rich interaction domain containing 2 / Q92833
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A5
Gene start: 44729474
Gene end: 44921643
  
Corresponding Affymetrix probe sets: 10404848 (MoGene1.0st)   1422697_s_at (Mouse Genome 430 2.0 Array)   1422698_s_at (Mouse Genome 430 2.0 Array)   1450710_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134675
Ensembl peptide - ENSMUSP00000037774
Ensembl peptide - ENSMUSP00000133653
Ensembl peptide - ENSMUSP00000133812
Ensembl peptide - ENSMUSP00000134205
Ensembl peptide - ENSMUSP00000134276
Ensembl peptide - ENSMUSP00000134302
Ensembl peptide - ENSMUSP00000134593
Ensembl peptide - ENSMUSP00000134630
Ensembl peptide - ENSMUSP00000134658
NCBI entrez gene - 16468     See in Manteia.
MGI - MGI:104813
RefSeq - XM_017315399
RefSeq - NM_001205043
RefSeq - NM_001205044
RefSeq - NM_021878
RefSeq - XM_006516855
RefSeq - XM_006516856
RefSeq - XM_006516858
RefSeq - XM_006516859
RefSeq - XM_006516860
RefSeq Peptide - NP_001191973
RefSeq Peptide - NP_068678
RefSeq Peptide - NP_001191972
swissprot - G3UZQ8
swissprot - G3UZT8
swissprot - G3UZW3
swissprot - G3UXT1
swissprot - G3UXE0
swissprot - Q62315
swissprot - G3UYY7
swissprot - G3UZ12
Ensembl - ENSMUSG00000038518
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jarid2aENSDARG00000060925Danio rerio
 Q1LVC2ENSDARG00000062268Danio rerio
 JARID2ENSGALG00000012702Gallus gallus
 JARID2ENSG00000008083Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdm5b / Q80Y84 / Lysine-specific demethylase 5B / Q9UGL1* / lysine demethylase 5B*ENSMUSG0000004220716
Kdm5a / Q3UXZ9 / Lysine-specific demethylase 5A / P29375* / lysine demethylase 5A*ENSMUSG0000003018015
Kdm5d / Q62240 / Lysine-specific demethylase 5D / Q9BY66* / lysine demethylase 5D*ENSMUSG0000005667315
Kdm5c / P41230 / Lysine-specific demethylase 5C / P41229* / lysine demethylase 5C*ENSMUSG0000002533215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001606  ARID DNA-binding domain
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR004198  Zinc finger, C5HC2-type
 IPR036431  ARID DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031061 negative regulation of histone methylation IDA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:0051574 positive regulation of histone H3-K9 methylation IDA
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0035097 histone methyltransferase complex IDA
 cellular_componentGO:0035098 ESC/E(Z) complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0000606 decreased hepatocyte number "fewer than normal number of parenchymal liver cells" [J:23170]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgaltm1Mak/Itgal+
Genetic Background: B6.129P2-Itgaltm1Mak

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C3.129P2-Jarid2jumonji

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

Allelic Composition: Jarid2Gt(pGT1.8geo)6Pgr/Jarid2Gt(pGT1.8geo)6Pgr
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C3.129P2-Jarid2jumonji

 MP:0004032 abnormal interventricular groove "malformation of the intendation dividing the two ventricles, comprised of the sulcus interventricularis anterior and the sulcus interventricularis posterior" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004062 dilated right atrium "an expansion in the volume of the right upper chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004837 abnormal neural fold formation "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C3.129P2-Jarid2jumonji

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Jarid2Gt(ROSA)1Gel/Jarid2Gt(ROSA)1Gel
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C3.129P2-Jarid2jumonji

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0011243 decreased fetal derived definitive erythrocyte cell number "reduced number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
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Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: C.129P2-Jarid2jumonji

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000029267 Mtf2 / Q02395 / Metal-response element-binding transcription factor 2 / Q9Y483*  / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / complex
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / complex
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex






 

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