ENSMUSG00000029267


Mus musculus

Features
Gene ID: ENSMUSG00000029267
  
Biological name :Mtf2
  
Synonyms : Metal-response element-binding transcription factor 2 / Mtf2 / Q02395
  
Possible biological names infered from orthology : Q9Y483
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 108065674
Gene end: 108109004
  
Corresponding Affymetrix probe sets: 10523905 (MoGene1.0st)   1418514_at (Mouse Genome 430 2.0 Array)   1418515_at (Mouse Genome 430 2.0 Array)   1418516_at (Mouse Genome 430 2.0 Array)   1445151_at (Mouse Genome 430 2.0 Array)   1449115_at (Mouse Genome 430 2.0 Array)   1459811_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121697
Ensembl peptide - ENSMUSP00000126297
Ensembl peptide - ENSMUSP00000137843
Ensembl peptide - ENSMUSP00000132596
Ensembl peptide - ENSMUSP00000130536
Ensembl peptide - ENSMUSP00000128797
Ensembl peptide - ENSMUSP00000126452
Ensembl peptide - ENSMUSP00000080278
Ensembl peptide - ENSMUSP00000108245
NCBI entrez gene - 17765     See in Manteia.
MGI - MGI:105050
RefSeq - XM_017320705
RefSeq - NM_001253877
RefSeq - NM_001253878
RefSeq - NM_001253879
RefSeq - NM_001253880
RefSeq - NM_013827
RefSeq - XM_006534808
RefSeq - XM_011249412
RefSeq - XM_011249416
RefSeq - XM_011249417
RefSeq - XM_017320704
RefSeq Peptide - NP_001240807
RefSeq Peptide - NP_001240806
RefSeq Peptide - NP_001240808
RefSeq Peptide - NP_001240809
RefSeq Peptide - NP_038855
swissprot - Q02395
swissprot - F6Q1Z6
swissprot - M0QWI3
swissprot - E9PYX9
swissprot - E9PZE8
swissprot - E9QAD3
swissprot - E9Q8G7
swissprot - E9Q5U4
swissprot - E9PZQ6
Ensembl - ENSMUSG00000029267
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtf2ENSDARG00000005590Danio rerio
 MTF2ENSGALG00000043087Gallus gallus
 MTF2ENSG00000143033Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phf19 / Q9CXG9 / PHD finger protein 19 / Q5T6S3*ENSMUSG0000002687343
Phf1 / Q9Z1B8 / PHD finger protein 1 / O43189*ENSMUSG0000002419335


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002999  Tudor domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR025894  Polycomb-like MTF2 factor 2, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0007379 segment specification IMP
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:0061086 negative regulation of histone H3-K27 methylation IMP
 biological_processGO:0061087 positive regulation of histone H3-K27 methylation IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000078 abnormal supraoccipital bone morphology "malformed upper part of the occipital bone" [J:61509]
Show

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Pcgf2tm1Hko/Pcgf2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Mtf2Gt(U3Betageo)1Ruiz/Mtf2Gt(U3Betageo)1Ruiz
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Suz12tm1Hko/Suz12+
Genetic Background: involves: C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Mtf2Gt(U3Betageo)1Ruiz/Mtf2Gt(U3Betageo)1Ruiz
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Suz12tm1Hko/Suz12+
Genetic Background: involves: C57BL/6

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Pcgf2tm1Hko/Pcgf2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hprtb-m3/Y,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: involves: 129S4/SvJae

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Mtf2Gt(U3Betageo)1Ruiz/Mtf2Gt(U3Betageo)1Ruiz
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Suz12tm1Hko/Suz12+
Genetic Background: involves: C57BL/6

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Pcgf2tm1Hko/Pcgf2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004342 scapular bone foramen "presence of a hole in either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Pcgf2tm1Hko/Pcgf2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtf2Gt(U3Betageo)1Ruiz/Mtf2Gt(U3Betageo)1Ruiz
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Suz12tm1Hko/Suz12+
Genetic Background: involves: C57BL/6

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Pcgf2tm1Hko/Pcgf2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtf2Gt(U3Betageo)1Ruiz/Mtf2Gt(U3Betageo)1Ruiz
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Suz12tm1Hko/Suz12+
Genetic Background: involves: C57BL/6

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Pcgf2tm1Hko/Pcgf2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtf2Gt(U3Betageo)1Ruiz/Mtf2Gt(U3Betageo)1Ruiz
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Suz12tm1Hko/Suz12+
Genetic Background: involves: C57BL/6

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Pcgf2tm1Hko/Pcgf2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004659 abnormal odontoid process "any structural anomaly of the large protuberance that projects upward from the cervical axis, around which the cervical atlas rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A02.835.232.834.151.383.668]
Show

Allelic Composition: Mtf2Gt(U3Betageo)1Ruiz/Mtf2Gt(U3Betageo)1Ruiz
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

 MP:0005269 abnormal occipital bone morphology "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Pcgf2tm1Hko/Pcgf2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mtf2tm1.1Hko/Mtf2+,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008009 delayed cellular replicative senescence "slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtf2Gt(U3Betageo)1Ruiz/Mtf2Gt(U3Betageo)1Ruiz
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mtf2Gt(U3Betageo)1Ruiz/Mtf2Gt(U3Betageo)1Ruiz
Genetic Background: involves: 129S2/SvPas

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Pcgf2tm1Hko/Pcgf2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mtf2tm1.1Hko/Mtf2+,Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030541 misaligned incisors "abnormal alignment of the upper and lower incisor teeth, usually resulting in malocclusion; in gnawing rodents, where incisors are rootless and grow continually, signs of incisor malocclusion include uneven wear patterns, sloping of the cutting edges, fractured teeth, altered pigmentation, and obvious pathological overgrowth of the incisors" [HP:0011062, https://books.google.com/books?isbn=0323394302, PMID:19622764]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / complex
 ENSMUSG00000038518 Jarid2 / Q62315 / Protein Jumonji / Q92833* / jumonji and AT-rich interaction domain containing 2*  / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr