ENSMUSG00000026873


Mus musculus

Features
Gene ID: ENSMUSG00000026873
  
Biological name :Phf19
  
Synonyms : PHD finger protein 19 / Phf19 / Q9CXG9
  
Possible biological names infered from orthology : Q5T6S3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 34893757
Gene end: 34914026
  
Corresponding Affymetrix probe sets: 10481931 (MoGene1.0st)   1427920_at (Mouse Genome 430 2.0 Array)   1431857_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028232
Ensembl peptide - ENSMUSP00000143954
NCBI entrez gene - 74016     See in Manteia.
MGI - MGI:1921266
RefSeq - XM_006498383
RefSeq - NM_028716
RefSeq - XM_006498380
RefSeq - XM_006498381
RefSeq - XM_006498382
RefSeq - XM_006498379
RefSeq Peptide - NP_082992
swissprot - Q9CXG9
swissprot - A0A0J9YU15
Ensembl - ENSMUSG00000026873
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phf19ENSDARG00000078050Danio rerio
 PHF19ENSGALG00000001595Gallus gallus
 PHF19ENSG00000119403Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mtf2 / Q02395 / Metal-response element-binding transcription factor 2 / Q9Y483*ENSMUSG0000002926744
Phf1 / Q9Z1B8 / PHD finger protein 1 / O43189*ENSMUSG0000002419337


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002999  Tudor domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR025894  Polycomb-like MTF2 factor 2, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:0061087 positive regulation of histone H3-K27 methylation ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0010507 shortened RR interval "reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0010511 shortened PR interval "decrease in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / complex
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / complex






 

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