ENSMUSG00000030619


Mus musculus

Features
Gene ID: ENSMUSG00000030619
  
Biological name :Eed
  
Synonyms : Eed / Polycomb protein EED / Q921E6
  
Possible biological names infered from orthology : embryonic ectoderm development / O75530
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D3
Gene start: 89954654
Gene end: 89980983
  
Corresponding Affymetrix probe sets: 10565486 (MoGene1.0st)   1448653_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102853
Ensembl peptide - ENSMUSP00000146892
Ensembl peptide - ENSMUSP00000146812
NCBI entrez gene - 13626     See in Manteia.
MGI - MGI:95286
RefSeq - NM_021876
RefSeq - XM_006507341
RefSeq Peptide - NP_068676
swissprot - A0A140LIN6
swissprot - Q921E6
swissprot - A0A140LIG5
Ensembl - ENSMUSG00000030619
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eedENSDARG00000099640Danio rerio
 EEDENSGALG00000014060Gallus gallus
 EEDENSG00000074266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily
 IPR037352  Polycomb protein EED


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006349 regulation of gene expression by genetic imprinting IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016571 histone methylation IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0061087 positive regulation of histone H3-K27 methylation IMP
 biological_processGO:0070734 histone H3-K27 methylation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000011 regulation of adaxial/abaxial pattern formation IGI
 cellular_componentGO:0001739 sex chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IEA
 cellular_componentGO:0045120 pronucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042054 histone methyltransferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046976 histone methyltransferase activity (H3-K27 specific) IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Eedtm1Sho/Eedtm1Sho,Eportm1(EGFP/cre)Uk/Epor+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004099 Dnmt1 / P13864 / DNA (cytosine-5)-methyltransferase 1 / P26358* / DNA methyltransferase 1*  / complex / reaction
 ENSMUSG00000020661 Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*  / reaction / complex
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / reaction / complex
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000024240 Epc1 / Q8C9X6 / Enhancer of polycomb homolog 1 / Q9H2F5*  / reaction / complex
 ENSMUSG00000026873 Phf19 / Q9CXG9 / PHD finger protein 19 / Q5T6S3*  / complex
 ENSMUSG00000030232 Aebp2 / Q9Z248 / Zinc finger protein AEBP2 / Q6ZN18* / AE binding protein 2*  / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / complex
 ENSMUSG00000038518 Jarid2 / Q62315 / Protein Jumonji / Q92833* / jumonji and AT-rich interaction domain containing 2*  / complex
 ENSMUSG00000027478 Dnmt3b / O88509 / DNA (cytosine-5)-methyltransferase 3B / Q9UBC3* / DNA methyltransferase 3 beta*  / reaction / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / complex
 ENSMUSG00000029267 Mtf2 / Q02395 / Metal-response element-binding transcription factor 2 / Q9Y483*  / complex
 ENSMUSG00000024193 Phf1 / Q9Z1B8 / PHD finger protein 1 / O43189*  / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction / complex






 

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