ENSMUSG00000024240


Mus musculus

Features
Gene ID: ENSMUSG00000024240
  
Biological name :Epc1
  
Synonyms : Enhancer of polycomb homolog 1 / Epc1 / Q8C9X6
  
Possible biological names infered from orthology : Q9H2F5
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 6435951
Gene end: 6516108
  
Corresponding Affymetrix probe sets: 10457302 (MoGene1.0st)   1418850_at (Mouse Genome 430 2.0 Array)   1429914_at (Mouse Genome 430 2.0 Array)   1458315_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028100
Ensembl peptide - ENSMUSP00000060599
Ensembl peptide - ENSMUSP00000111536
Ensembl peptide - ENSMUSP00000117601
NCBI entrez gene - 13831     See in Manteia.
MGI - MGI:1278322
RefSeq - NM_001276350
RefSeq - NM_007935
RefSeq - NM_027497
RefSeq Peptide - NP_001263279
RefSeq Peptide - NP_031961
RefSeq Peptide - NP_081773
swissprot - Q8C9X6
swissprot - D3Z3Q6
swissprot - Q6PBH3
Ensembl - ENSMUSG00000024240
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epc1aENSDARG00000101579Danio rerio
 epc1bENSDARG00000060054Danio rerio
 EPC1ENSGALG00000007169Gallus gallus
 EPC1ENSG00000120616Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epc2 / Q8C0I4 / Enhancer of polycomb homolog 2 / Q52LR7*ENSMUSG0000006949553


Protein motifs (from Interpro)
Interpro ID Name
 IPR009607  Enhancer of polycomb, C-terminal
 IPR019542  Enhancer of polycomb-like, N-terminal
 IPR024943  Enhancer of polycomb protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0035886 vascular smooth muscle cell differentiation IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043967 histone H4 acetylation ISO
 biological_processGO:0043968 histone H2A acetylation ISO
 biological_processGO:0045814 negative regulation of gene expression, epigenetic ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0051155 positive regulation of striated muscle cell differentiation ISA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0031965 nuclear membrane ISO
 cellular_componentGO:0032777 Piccolo NuA4 histone acetyltransferase complex IEA
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IBA


Pathways (from Reactome)
Pathway description
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003062 abnormal coping response "altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli" [RGD:Rat Genome Database submission]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / complex / reaction
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / complex / reaction
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / reaction / complex
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / reaction / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex / reaction
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / reaction / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction / complex






 

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