ENSG00000120616


Homo sapiens

Features
Gene ID: ENSG00000120616
  
Biological name :EPC1
  
Synonyms : enhancer of polycomb homolog 1 / EPC1 / Q9H2F5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p11.22
Gene start: 32267751
Gene end: 32378798
  
Corresponding Affymetrix probe sets: 223875_s_at (Human Genome U133 Plus 2.0 Array)   225417_at (Human Genome U133 Plus 2.0 Array)   234969_s_at (Human Genome U133 Plus 2.0 Array)   238633_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263062
Ensembl peptide - ENSP00000318559
Ensembl peptide - ENSP00000364251
NCBI entrez gene - 80314     See in Manteia.
OMIM - 610999
RefSeq - XM_006717510
RefSeq - NM_001272004
RefSeq - NM_001272019
RefSeq - NM_001282391
RefSeq - NM_025209
RefSeq Peptide - NP_001258948
RefSeq Peptide - NP_001269320
RefSeq Peptide - NP_079485
RefSeq Peptide - NP_001258933
swissprot - Q9H2F5
Ensembl - ENSG00000120616
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epc1aENSDARG00000101579Danio rerio
 epc1bENSDARG00000060054Danio rerio
 EPC1ENSGALG00000007169Gallus gallus
 Epc1ENSMUSG00000024240Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPC2 / Q52LR7 / enhancer of polycomb homolog 2ENSG0000013599953


Protein motifs (from Interpro)
Interpro ID Name
 IPR009607  Enhancer of polycomb, C-terminal
 IPR019542  Enhancer of polycomb-like, N-terminal
 IPR024943  Enhancer of polycomb protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0035886 vascular smooth muscle cell differentiation IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043967 histone H4 acetylation IDA
 biological_processGO:0043968 histone H2A acetylation IDA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0032777 Piccolo NuA4 histone acetyltransferase complex IDA
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex IDA
 molecular_functionGO:0004402 histone acetyltransferase activity IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
HATs acetylate histones
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000102054 RBBP7 / Q16576 / RB binding protein 7, chromatin remodeling factor  / reaction / complex
 ENSG00000106462 EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunit  / reaction / complex
 ENSG00000178691 SUZ12 / Q15022 / SUZ12 polycomb repressive complex 2 subunit  / reaction / complex
 ENSG00000074266 EED / O75530 / embryonic ectoderm development  / complex / reaction
 ENSG00000162521 RBBP4 / Q09028 / RB binding protein 4, chromatin remodeling factor  / complex / reaction
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / reaction / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex / reaction






 

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