ENSG00000102054


Homo sapiens

Features
Gene ID: ENSG00000102054
  
Biological name :RBBP7
  
Synonyms : Q16576 / RB binding protein 7, chromatin remodeling factor / RBBP7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p22.2
Gene start: 16839283
Gene end: 16870414
  
Corresponding Affymetrix probe sets: 201092_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392714
Ensembl peptide - ENSP00000402796
Ensembl peptide - ENSP00000417791
Ensembl peptide - ENSP00000417507
Ensembl peptide - ENSP00000415747
Ensembl peptide - ENSP00000369424
Ensembl peptide - ENSP00000369427
Ensembl peptide - ENSP00000386068
NCBI entrez gene - 5931     See in Manteia.
OMIM - 300825
RefSeq - NM_002893
RefSeq - NM_001198719
RefSeq Peptide - NP_001185648
RefSeq Peptide - NP_002884
swissprot - Q5JNZ6
swissprot - Q5JP01
swissprot - Q5JP02
swissprot - E9PC52
swissprot - Q6FHQ0
swissprot - C9JAJ9
swissprot - C9J7L0
swissprot - Q16576
Ensembl - ENSG00000102054
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbb4lENSDARG00000015208Danio rerio
 RBBP7ENSGALG00000016546Gallus gallus
 Rbbp7ENSMUSG00000031353Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RBBP4 / Q09028 / RB binding protein 4, chromatin remodeling factorENSG0000016252180


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR022052  Histone-binding protein RBBP4, N-terminal
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045814 negative regulation of gene expression, epigenetic TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 biological_processGO:0070370 cellular heat acclimation IDA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016581 NuRD complex IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004407 histone deacetylase activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
HATs acetylate histones
RMTs methylate histone arginines
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Deposition of new CENPA-containing nucleosomes at the centromere
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Neddylation
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120616 EPC1 / Q9H2F5 / enhancer of polycomb homolog 1  / reaction / complex
 ENSG00000102974 CTCF / P49711 / CCCTC-binding factor  / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / complex / reaction
 ENSG00000119403 PHF19 / Q5T6S3 / PHD finger protein 19  / complex
 ENSG00000178691 SUZ12 / Q15022 / SUZ12 polycomb repressive complex 2 subunit  / complex
 ENSG00000088305 DNMT3B / Q9UBC3 / DNA methyltransferase 3 beta  / reaction / complex
 ENSG00000119772 DNMT3A / Q9Y6K1 / DNA methyltransferase 3 alpha  / complex / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex
 ENSG00000128708 HAT1 / O14929 / histone acetyltransferase 1  / complex
 ENSG00000106462 EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunit  / complex
 ENSG00000130816 DNMT1 / P26358 / DNA methyltransferase 1  / complex / reaction
 ENSG00000139154 AEBP2 / Q6ZN18 / AE binding protein 2  / complex
 ENSG00000143033 MTF2 / Q9Y483 / metal response element binding transcription factor 2  / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction / complex
 ENSG00000074266 EED / O75530 / embryonic ectoderm development  / complex
 ENSG00000008083 JARID2 / Q92833 / jumonji and AT-rich interaction domain containing 2  / complex
 ENSG00000112511 PHF1 / O43189 / PHD finger protein 1  / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / reaction / complex






 

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