ENSG00000112511


Homo sapiens

Features
Gene ID: ENSG00000112511
  
Biological name :PHF1
  
Synonyms : O43189 / PHD finger protein 1 / PHF1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.32
Gene start: 33410399
Gene end: 33416453
  
Corresponding Affymetrix probe sets: 202928_s_at (Human Genome U133 Plus 2.0 Array)   40446_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363636
Ensembl peptide - ENSP00000479423
Ensembl peptide - ENSP00000434347
Ensembl peptide - ENSP00000432419
Ensembl peptide - ENSP00000410494
Ensembl peptide - ENSP00000404788
Ensembl peptide - ENSP00000392697
Ensembl peptide - ENSP00000363640
NCBI entrez gene - 5252     See in Manteia.
OMIM - 602881
RefSeq - XM_011514662
RefSeq - XM_011514670
RefSeq - XM_011514669
RefSeq - XM_011514666
RefSeq - XM_011514665
RefSeq - XM_011514664
RefSeq - NM_002636
RefSeq - NM_024165
RefSeq - XM_017010939
RefSeq - XM_011514663
RefSeq Peptide - NP_002627
RefSeq Peptide - NP_077084
swissprot - O43189
swissprot - E9PQZ5
swissprot - A0A087WVG4
swissprot - A0A1U9X8A3
swissprot - A2AB22
swissprot - A2AB23
swissprot - A2AB25
swissprot - E9PQT8
Ensembl - ENSG00000112511
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phf1ENSDARG00000057439Danio rerio
 Phf1ENSMUSG00000024193Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PHF19 / Q5T6S3 / PHD finger protein 19ENSG0000011940340
MTF2 / Q9Y483 / metal response element binding transcription factor 2ENSG0000014303339


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002999  Tudor domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR025894  Polycomb-like MTF2 factor 2, C-terminal domain
 IPR031202  PHD finger protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0031060 regulation of histone methylation IEA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic TAS
 biological_processGO:0061086 negative regulation of histone H3-K27 methylation IMP
 biological_processGO:0061087 positive regulation of histone H3-K27 methylation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 cellular_componentGO:0035861 site of double-strand break IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162521 RBBP4 / Q09028 / RB binding protein 4, chromatin remodeling factor  / complex
 ENSG00000074266 EED / O75530 / embryonic ectoderm development  / complex
 ENSG00000178691 SUZ12 / Q15022 / SUZ12 polycomb repressive complex 2 subunit  / complex
 ENSG00000102054 RBBP7 / Q16576 / RB binding protein 7, chromatin remodeling factor  / complex
 ENSG00000106462 EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunit  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr