ENSG00000162521


Homo sapiens

Features
Gene ID: ENSG00000162521
  
Biological name :RBBP4
  
Synonyms : Q09028 / RB binding protein 4, chromatin remodeling factor / RBBP4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p35.1
Gene start: 32651142
Gene end: 32686211
  
Corresponding Affymetrix probe sets: 210371_s_at (Human Genome U133 Plus 2.0 Array)   217301_x_at (Human Genome U133 Plus 2.0 Array)   225396_at (Human Genome U133 Plus 2.0 Array)   237333_at (Human Genome U133 Plus 2.0 Array)   239071_at (Human Genome U133 Plus 2.0 Array)   244872_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432780
Ensembl peptide - ENSP00000437210
Ensembl peptide - ENSP00000436986
Ensembl peptide - ENSP00000436663
Ensembl peptide - ENSP00000436565
Ensembl peptide - ENSP00000434925
Ensembl peptide - ENSP00000433805
Ensembl peptide - ENSP00000362584
Ensembl peptide - ENSP00000362592
Ensembl peptide - ENSP00000389437
Ensembl peptide - ENSP00000396057
Ensembl peptide - ENSP00000398242
Ensembl peptide - ENSP00000432298
Ensembl peptide - ENSP00000432774
NCBI entrez gene - 5928     See in Manteia.
OMIM - 602923
RefSeq - NM_001135256
RefSeq - NM_005610
RefSeq - NM_001135255
RefSeq Peptide - NP_001128727
RefSeq Peptide - NP_001128728
RefSeq Peptide - NP_005601
swissprot - H0YEU5
swissprot - H0YF10
swissprot - E9PNS6
swissprot - Q09028
swissprot - E9PNS2
swissprot - E9PND5
swissprot - E9PIC4
swissprot - C9JPP3
swissprot - H0YCT5
swissprot - H0YDK2
Ensembl - ENSG00000162521
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbbp4ENSDARG00000029058Danio rerio
 RBBP4ENSGALG00000003522Gallus gallus
 Rbbp4ENSMUSG00000057236Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RBBP7 / Q16576 / RB binding protein 7, chromatin remodeling factorENSG0000010205488


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR022052  Histone-binding protein RBBP4, N-terminal
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006335 DNA replication-dependent nucleosome assembly IDA
 biological_processGO:0006336 DNA replication-independent nucleosome assembly IDA
 biological_processGO:0006338 chromatin remodeling IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0031497 chromatin assembly IDA
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0043044 ATP-dependent chromatin remodeling HDA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic TAS
 biological_processGO:0051726 regulation of cell cycle TAS
 biological_processGO:0060416 response to growth hormone IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016580 Sin3 complex NAS
 cellular_componentGO:0016581 NuRD complex NAS
 cellular_componentGO:0016589 NURF complex IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0033186 CAF-1 complex IDA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding HDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding HDA
 molecular_functionGO:0004407 histone deacetylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008094 DNA-dependent ATPase activity IDA
 molecular_functionGO:0031492 nucleosomal DNA binding HDA
 molecular_functionGO:0042393 histone binding NAS
 molecular_functionGO:0042826 histone deacetylase binding IPI


Pathways (from Reactome)
Pathway description
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
Polo-like kinase mediated events
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Activation of E2F1 target genes at G1/S
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Deposition of new CENPA-containing nucleosomes at the centromere
Regulation of TP53 Activity through Acetylation
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120616 EPC1 / Q9H2F5 / enhancer of polycomb homolog 1  / complex / reaction
 ENSG00000102974 CTCF / P49711 / CCCTC-binding factor  / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / complex / reaction
 ENSG00000119403 PHF19 / Q5T6S3 / PHD finger protein 19  / complex
 ENSG00000178691 SUZ12 / Q15022 / SUZ12 polycomb repressive complex 2 subunit  / complex
 ENSG00000008083 JARID2 / Q92833 / jumonji and AT-rich interaction domain containing 2  / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex / reaction
 ENSG00000112511 PHF1 / O43189 / PHD finger protein 1  / complex
 ENSG00000143033 MTF2 / Q9Y483 / metal response element binding transcription factor 2  / complex
 ENSG00000074266 EED / O75530 / embryonic ectoderm development  / complex
 ENSG00000088305 DNMT3B / Q9UBC3 / DNA methyltransferase 3 beta  / reaction / complex
 ENSG00000106462 EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunit  / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction / complex
 ENSG00000139154 AEBP2 / Q6ZN18 / AE binding protein 2  / complex
 ENSG00000119772 DNMT3A / Q9Y6K1 / DNA methyltransferase 3 alpha  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex
 ENSG00000130816 DNMT1 / P26358 / DNA methyltransferase 1  / complex / reaction
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / reaction / complex






 

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