ENSG00000008083


Homo sapiens

Features
Gene ID: ENSG00000008083
  
Biological name :JARID2
  
Synonyms : JARID2 / jumonji and AT-rich interaction domain containing 2 / Q92833
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.3
Gene start: 15246296
Gene end: 15522040
  
Corresponding Affymetrix probe sets: 203297_s_at (Human Genome U133 Plus 2.0 Array)   203298_s_at (Human Genome U133 Plus 2.0 Array)   240674_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341280
Ensembl peptide - ENSP00000380478
NCBI entrez gene - 3720     See in Manteia.
OMIM - 601594
RefSeq - XM_017010835
RefSeq - NM_001267040
RefSeq - NM_004973
RefSeq - XM_011514579
RefSeq - XM_017010833
RefSeq - XM_017010834
RefSeq - XM_005249089
RefSeq Peptide - NP_004964
RefSeq Peptide - NP_001253969
swissprot - Q92833
Ensembl - ENSG00000008083
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jarid2aENSDARG00000060925Danio rerio
 Q1LVC2ENSDARG00000062268Danio rerio
 JARID2ENSGALG00000012702Gallus gallus
 Jarid2ENSMUSG00000038518Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM5B / Q9UGL1 / lysine demethylase 5BENSG0000011713916
KDM5C / P41229 / lysine demethylase 5CENSG0000012601215
KDM5D / Q9BY66 / lysine demethylase 5DENSG0000001281715
KDM5A / P29375 / lysine demethylase 5AENSG0000007361415


Protein motifs (from Interpro)
Interpro ID Name
 IPR001606  ARID DNA-binding domain
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR004198  Zinc finger, C5HC2-type
 IPR036431  ARID DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031061 negative regulation of histone methylation ISS
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0048536 spleen development IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048863 stem cell differentiation ISS
 biological_processGO:0051574 positive regulation of histone H3-K9 methylation ISS
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0035097 histone methyltransferase complex ISS
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0008134 transcription factor binding IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000102054 RBBP7 / Q16576 / RB binding protein 7, chromatin remodeling factor  / complex
 ENSG00000143033 MTF2 / Q9Y483 / metal response element binding transcription factor 2  / complex
 ENSG00000162521 RBBP4 / Q09028 / RB binding protein 4, chromatin remodeling factor  / complex
 ENSG00000074266 EED / O75530 / embryonic ectoderm development  / complex
 ENSG00000106462 EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunit  / complex
 ENSG00000178691 SUZ12 / Q15022 / SUZ12 polycomb repressive complex 2 subunit  / complex






 

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