ENSG00000012817


Homo sapiens

Features
Gene ID: ENSG00000012817
  
Biological name :KDM5D
  
Synonyms : KDM5D / lysine demethylase 5D / Q9BY66
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: Y
Strand: -1
Band: q11.223
Gene start: 19703865
Gene end: 19744939
  
Corresponding Affymetrix probe sets: 206700_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398543
Ensembl peptide - ENSP00000389433
Ensembl peptide - ENSP00000416377
Ensembl peptide - ENSP00000444293
Ensembl peptide - ENSP00000322408
Ensembl peptide - ENSP00000372256
NCBI entrez gene - 8284     See in Manteia.
OMIM - 426000
RefSeq - XM_011531468
RefSeq - NM_001146705
RefSeq - NM_001146706
RefSeq - NM_004653
RefSeq - XM_005262560
RefSeq - XM_005262561
RefSeq Peptide - NP_004644
RefSeq Peptide - NP_001140178
RefSeq Peptide - NP_001140177
swissprot - C9JGA3
swissprot - H7BZF9
swissprot - E9PFH2
swissprot - Q9BY66
Ensembl - ENSG00000012817
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm5cENSDARG00000006124Danio rerio
 Kdm5dENSMUSG00000056673Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM5C / P41229 / lysine demethylase 5CENSG0000012601286
KDM5A / P29375 / lysine demethylase 5AENSG0000007361451
KDM5B / Q9UGL1 / lysine demethylase 5BENSG0000011713945
JARID2 / Q92833 / jumonji and AT-rich interaction domain containing 2ENSG0000000808312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001606  ARID DNA-binding domain
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR004198  Zinc finger, C5HC2-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013637  Lysine-specific demethylase-like domain
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR036431  ARID DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002457 T cell antigen processing and presentation IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0034720 histone H3-K4 demethylation IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060765 regulation of androgen receptor signaling pathway IMP
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0032453 histone demethylase activity (H3-K4 specific) IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding IDA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000027 Azoospermia 
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 HP:0001450 Y-linked inheritance "A mode of inheritance that is observed for traits related to a gene encoded on the Y chromosome." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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