ENSG00000073614


Homo sapiens

Features
Gene ID: ENSG00000073614
  
Biological name :KDM5A
  
Synonyms : KDM5A / lysine demethylase 5A / P29375
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.33
Gene start: 280129
Gene end: 389454
  
Corresponding Affymetrix probe sets: 202040_s_at (Human Genome U133 Plus 2.0 Array)   215698_at (Human Genome U133 Plus 2.0 Array)   226367_at (Human Genome U133 Plus 2.0 Array)   226371_at (Human Genome U133 Plus 2.0 Array)   230226_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443854
Ensembl peptide - ENSP00000444251
Ensembl peptide - ENSP00000382688
Ensembl peptide - ENSP00000438203
Ensembl peptide - ENSP00000440622
NCBI entrez gene - 5927     See in Manteia.
OMIM - 180202
RefSeq - NM_001042603
RefSeq Peptide - NP_001036068
swissprot - F5GZR8
swissprot - E7EV89
swissprot - P29375
swissprot - F5H322
swissprot - F5GZ99
Ensembl - ENSG00000073614
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KDM5AENSGALG00000012986Gallus gallus
 Kdm5aENSMUSG00000030180Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM5C / P41229 / lysine demethylase 5CENSG0000012601249
KDM5B / Q9UGL1 / lysine demethylase 5BENSG0000011713949
KDM5D / Q9BY66 / lysine demethylase 5DENSG0000001281747
JARID2 / Q92833 / jumonji and AT-rich interaction domain containing 2ENSG0000000808311


Protein motifs (from Interpro)
Interpro ID Name
 IPR001606  ARID DNA-binding domain
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR004198  Zinc finger, C5HC2-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013637  Lysine-specific demethylase-like domain
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR036431  ARID DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0034720 histone H3-K4 demethylation IDA
 biological_processGO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1901726 negative regulation of histone deacetylase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex IDA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0034647 histone demethylase activity (H3-trimethyl-K4 specific) IDA
 molecular_functionGO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) IDA
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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