ENSG00000117139


Homo sapiens

Features
Gene ID: ENSG00000117139
  
Biological name :KDM5B
  
Synonyms : KDM5B / lysine demethylase 5B / Q9UGL1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.1
Gene start: 202724491
Gene end: 202809470
  
Corresponding Affymetrix probe sets: 201547_at (Human Genome U133 Plus 2.0 Array)   201548_s_at (Human Genome U133 Plus 2.0 Array)   201549_x_at (Human Genome U133 Plus 2.0 Array)   211202_s_at (Human Genome U133 Plus 2.0 Array)   235285_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473481
Ensembl peptide - ENSP00000235790
Ensembl peptide - ENSP00000356233
Ensembl peptide - ENSP00000356234
NCBI entrez gene - 10765     See in Manteia.
OMIM - 605393
RefSeq - XM_011509092
RefSeq - NM_001314042
RefSeq - NM_006618
RefSeq - XM_011509088
RefSeq - XM_011509090
RefSeq - XM_011509091
RefSeq Peptide - NP_001300971
RefSeq Peptide - NP_006609
swissprot - R4GN45
swissprot - B3KV94
swissprot - Q9UGL1
Ensembl - ENSG00000117139
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm5baENSDARG00000057093Danio rerio
 kdm5bbENSDARG00000003098Danio rerio
 KDM5BENSGALG00000038948Gallus gallus
 Kdm5bENSMUSG00000042207Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM5A / P29375 / lysine demethylase 5AENSG0000007361452
KDM5C / P41229 / lysine demethylase 5CENSG0000012601245
KDM5D / Q9BY66 / lysine demethylase 5DENSG0000001281744
JARID2 / Q92833 / jumonji and AT-rich interaction domain containing 2ENSG0000000808312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001606  ARID DNA-binding domain
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR004198  Zinc finger, C5HC2-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013637  Lysine-specific demethylase-like domain
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR036431  ARID DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0034720 histone H3-K4 demethylation IEA
 biological_processGO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060763 mammary duct terminal end bud growth IEA
 biological_processGO:0060992 response to fungicide IEA
 biological_processGO:0061038 uterus morphogenesis IEA
 biological_processGO:0070306 lens fiber cell differentiation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000864 regulation of estradiol secretion IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IMP
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0032453 histone demethylase activity (H3-K4 specific) IDA
 molecular_functionGO:0034647 histone demethylase activity (H3-trimethyl-K4 specific) IDA
 molecular_functionGO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) IDA
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:1990837 sequence-specific double-stranded DNA binding IMP


Pathways (from Reactome)
Pathway description
HDMs demethylate histones
TFAP2 (AP-2) family regulates transcription of cell cycle factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087510 Q92754 / TFAP2C / transcription factor AP-2 gamma  / complex / reaction
 ENSG00000136997 MYC / P01106 / MYC proto-oncogene, bHLH transcription factor  / reaction / complex






 

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