ENSGALG00000038948


Gallus gallus

Features
Gene ID: ENSGALG00000038948
  
Biological name :KDM5B
  
Synonyms : KDM5B / Lysine-specific demethylase 5B / Q5F3R2
  
Possible biological names infered from orthology : lysine demethylase 5B / Q80Y84 / Q9UGL1
  
Species: Gallus gallus
  
Chr. number: 26
Strand: 1
Band:
Gene start: 534491
Gene end: 563446
  
Corresponding Affymetrix probe sets: GgaAffx.25937.1.S1_s_at (Chicken Array)   GgaAffx.25937.3.S1_at (Chicken Array)   GgaAffx.25937.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000056668
Ensembl peptide - ENSGALP00000045209
NCBI entrez gene - 421168     See in Manteia.
RefSeq - NM_001031029
RefSeq Peptide - NP_001026200
swissprot - Q5F3R2
swissprot - A0A1D5NXV8
Ensembl - ENSGALG00000038948
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm5baENSDARG00000057093Danio rerio
 kdm5bbENSDARG00000003098Danio rerio
 KDM5BENSG00000117139Homo sapiens
 Kdm5bENSMUSG00000042207Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM5A / lysine demethylase 5A / P29375* / Q3UXZ9* / Lysine-specific demethylase 5A *ENSGALG0000001298650
JARID2 / protein Jumonji / Q62315* / Q92833* / jumonji and AT-rich interaction domain containing 2*ENSGALG0000001270212


Protein motifs (from Interpro)
Interpro ID Name
 IPR001606  ARID DNA-binding domain
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR004198  Zinc finger, C5HC2-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013637  Lysine-specific demethylase-like domain
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0034720 histone H3-K4 demethylation ISS
 biological_processGO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060763 mammary duct terminal end bud growth IEA
 biological_processGO:0061038 uterus morphogenesis IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000864 regulation of estradiol secretion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032453 histone demethylase activity (H3-K4 specific) ISS
 molecular_functionGO:0034647 histone demethylase activity (H3-trimethyl-K4 specific) ISS
 molecular_functionGO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) ISS
 molecular_functionGO:0042393 histone binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:1990837 sequence-specific double-stranded DNA binding IEA


Pathways (from Reactome)
Pathway description
TFAP2 (AP-2) family regulates transcription of cell cycle factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007690 TFAP2C / transcription factor AP-2 gamma / Q61312* / Q92754*  / reaction / complex
 ENSGALG00000033631 MYC / P01109 / Myc proto-oncogene protein / Bmyc* / Q6P8Z1* / P01106* / P01108* / Protein B-Myc * / myelocytomatosis oncogene* / MYC proto-oncogene, bHLH transcription factor*  / complex / reaction






 

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