ENSMUSG00000042207


Mus musculus

Features
Gene ID: ENSMUSG00000042207
  
Biological name :Kdm5b
  
Synonyms : Kdm5b / Lysine-specific demethylase 5B / Q80Y84
  
Possible biological names infered from orthology : lysine demethylase 5B / Q9UGL1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 134560171
Gene end: 134635285
  
Corresponding Affymetrix probe sets: 10350046 (MoGene1.0st)   1427142_s_at (Mouse Genome 430 2.0 Array)   1427143_at (Mouse Genome 430 2.0 Array)   1442278_at (Mouse Genome 430 2.0 Array)   1457482_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038138
Ensembl peptide - ENSMUSP00000107817
NCBI entrez gene - 75605     See in Manteia.
MGI - MGI:1922855
RefSeq - XM_017312617
RefSeq - NM_152895
RefSeq - XM_011248090
RefSeq - XM_017312616
RefSeq Peptide - NP_690855
swissprot - Q80Y84
Ensembl - ENSMUSG00000042207
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm5baENSDARG00000057093Danio rerio
 kdm5bbENSDARG00000003098Danio rerio
 KDM5BENSGALG00000038948Gallus gallus
 KDM5BENSG00000117139Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdm5a / Q3UXZ9 / Lysine-specific demethylase 5A / P29375* / lysine demethylase 5A*ENSMUSG0000003018053
Kdm5c / P41230 / Lysine-specific demethylase 5C / P41229* / lysine demethylase 5C*ENSMUSG0000002533246
Kdm5d / Q62240 / Lysine-specific demethylase 5D / Q9BY66* / lysine demethylase 5D*ENSMUSG0000005667345
Jarid2 / Q62315 / Protein Jumonji / Q92833* / jumonji and AT-rich interaction domain containing 2*ENSMUSG0000003851813


Protein motifs (from Interpro)
Interpro ID Name
 IPR001606  ARID DNA-binding domain
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR004198  Zinc finger, C5HC2-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013637  Lysine-specific demethylase-like domain
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR036431  ARID DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007338 single fertilization IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0034720 histone H3-K4 demethylation ISS
 biological_processGO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific IEA
 biological_processGO:0042752 regulation of circadian rhythm NAS
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IMP
 biological_processGO:0060763 mammary duct terminal end bud growth IMP
 biological_processGO:0060992 response to fungicide IEA
 biological_processGO:0061038 uterus morphogenesis IMP
 biological_processGO:0070306 lens fiber cell differentiation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000864 regulation of estradiol secretion IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032453 histone demethylase activity (H3-K4 specific) ISO
 molecular_functionGO:0034647 histone demethylase activity (H3-trimethyl-K4 specific) ISS
 molecular_functionGO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) ISS
 molecular_functionGO:0042393 histone binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:1990837 sequence-specific double-stranded DNA binding ISO


Pathways (from Reactome)
Pathway description
HDMs demethylate histones
TFAP2 (AP-2) family regulates transcription of cell cycle factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Kdm5bGt(RRO123)Byg/Kdm5bGt(RRO123)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdm5bGt(RRO123)Byg/Kdm5bGt(RRO123)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028640 Q61312 / Tfap2c / transcription factor AP-2, gamma / Q92754*  / complex / reaction
 ENSMUSG00000022346 Myc / P01108 / myelocytomatosis oncogene / P01106* / MYC proto-oncogene, bHLH transcription factor*  / complex / reaction






 

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