ENSG00000143033


Homo sapiens

Features
Gene ID: ENSG00000143033
  
Biological name :MTF2
  
Synonyms : metal response element binding transcription factor 2 / MTF2 / Q9Y483
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p22.1
Gene start: 93079235
Gene end: 93139081
  
Corresponding Affymetrix probe sets: 203345_s_at (Human Genome U133 Plus 2.0 Array)   203346_s_at (Human Genome U133 Plus 2.0 Array)   203347_s_at (Human Genome U133 Plus 2.0 Array)   209704_at (Human Genome U133 Plus 2.0 Array)   209705_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444962
Ensembl peptide - ENSP00000359321
Ensembl peptide - ENSP00000359326
Ensembl peptide - ENSP00000443295
NCBI entrez gene - 22823     See in Manteia.
OMIM - 609882
RefSeq - XM_017000679
RefSeq - NM_001164391
RefSeq - NM_001164392
RefSeq - NM_001164393
RefSeq - NM_007358
RefSeq - XM_011541016
RefSeq - XM_011541017
RefSeq - XM_011541019
RefSeq - XM_017000676
RefSeq - XM_017000677
RefSeq - XM_017000678
RefSeq Peptide - NP_001157865
RefSeq Peptide - NP_001157863
RefSeq Peptide - NP_001157864
RefSeq Peptide - NP_031384
swissprot - Q9Y483
swissprot - Q96G26
swissprot - B4DZG1
Ensembl - ENSG00000143033
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtf2ENSDARG00000005590Danio rerio
 MTF2ENSGALG00000043087Gallus gallus
 Mtf2ENSMUSG00000029267Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PHF19 / Q5T6S3 / PHD finger protein 19ENSG0000011940342
PHF1 / O43189 / PHD finger protein 1ENSG0000011251137


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002999  Tudor domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR025894  Polycomb-like MTF2 factor 2, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0007379 segment specification IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048863 stem cell differentiation IEA
 biological_processGO:0061086 negative regulation of histone H3-K27 methylation IEA
 biological_processGO:0061087 positive regulation of histone H3-K27 methylation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0035098 ESC/E(Z) complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000074266 EED / O75530 / embryonic ectoderm development  / complex
 ENSG00000178691 SUZ12 / Q15022 / SUZ12 polycomb repressive complex 2 subunit  / complex
 ENSG00000106462 EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunit  / complex
 ENSG00000102054 RBBP7 / Q16576 / RB binding protein 7, chromatin remodeling factor  / complex
 ENSG00000008083 JARID2 / Q92833 / jumonji and AT-rich interaction domain containing 2  / complex
 ENSG00000162521 RBBP4 / Q09028 / RB binding protein 4, chromatin remodeling factor  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr