ENSMUSG00000031353


Mus musculus

Features
Gene ID: ENSMUSG00000031353
  
Biological name :Rbbp7
  
Synonyms : Q60973 / Rbbp7 / retinoblastoma binding protein 7, chromatin remodeling factor
  
Possible biological names infered from orthology : Q16576 / RB binding protein 7, chromatin remodeling factor
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F4
Gene start: 162760402
Gene end: 162779092
  
Corresponding Affymetrix probe sets: 10602164 (MoGene1.0st)   10603011 (MoGene1.0st)   1415775_at (Mouse Genome 430 2.0 Array)   1456227_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107946
Ensembl peptide - ENSMUSP00000115354
Ensembl peptide - ENSMUSP00000114734
Ensembl peptide - ENSMUSP00000033720
Ensembl peptide - ENSMUSP00000107945
NCBI entrez gene - 245688     See in Manteia.
MGI - MGI:1194910
RefSeq - NM_009031
RefSeq Peptide - NP_033057
swissprot - F6ZLC6
swissprot - A2AFJ1
swissprot - Q60973
swissprot - A2AFI9
swissprot - F6U539
Ensembl - ENSMUSG00000031353
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbb4lENSDARG00000015208Danio rerio
 RBBP7ENSGALG00000016546Gallus gallus
 RBBP7ENSG00000102054Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*ENSMUSG0000005723689


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR022052  Histone-binding protein RBBP4, N-terminal
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0070370 cellular heat acclimation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016581 NuRD complex IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IEA
 molecular_functionGO:0003723 RNA binding IPI
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
HATs acetylate histones
RMTs methylate histone arginines
Deposition of new CENPA-containing nucleosomes at the centromere
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Neddylation
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxw4Dac/Fbxw4+,mdac/mdac
Genetic Background: involves: SM/Ckc * BALB/cByJ

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxw4Dac/Fbxw4+,mdac/mdac
Genetic Background: involves: SM/Ckc * BALB/cByJ

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004099 Dnmt1 / P13864 / DNA (cytosine-5)-methyltransferase 1 / P26358* / DNA methyltransferase 1*  / reaction / complex
 ENSMUSG00000020661 Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*  / complex / reaction
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / complex / reaction
 ENSMUSG00000024240 Epc1 / Q8C9X6 / Enhancer of polycomb homolog 1 / Q9H2F5*  / reaction / complex
 ENSMUSG00000026873 Phf19 / Q9CXG9 / PHD finger protein 19 / Q5T6S3*  / complex
 ENSMUSG00000030232 Aebp2 / Q9Z248 / Zinc finger protein AEBP2 / Q6ZN18* / AE binding protein 2*  / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000029267 Mtf2 / Q02395 / Metal-response element-binding transcription factor 2 / Q9Y483*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000024193 Phf1 / Q9Z1B8 / PHD finger protein 1 / O43189*  / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction / complex
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction / complex
 ENSMUSG00000027018 Hat1 / Q8BY71 / Histone acetyltransferase type B catalytic subunit / O14929* / histone acetyltransferase 1*  / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000038518 Jarid2 / Q62315 / Protein Jumonji / Q92833* / jumonji and AT-rich interaction domain containing 2*  / complex
 ENSMUSG00000027478 Dnmt3b / O88509 / DNA (cytosine-5)-methyltransferase 3B / Q9UBC3* / DNA methyltransferase 3 beta*  / reaction / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction / complex






 

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