ENSMUSG00000030232


Mus musculus

Features
Gene ID: ENSMUSG00000030232
  
Biological name :Aebp2
  
Synonyms : Aebp2 / Q9Z248 / Zinc finger protein AEBP2
  
Possible biological names infered from orthology : AE binding protein 2 / Q6ZN18
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G2
Gene start: 140622663
Gene end: 140678472
  
Corresponding Affymetrix probe sets: 10542557 (MoGene1.0st)   1421021_at (Mouse Genome 430 2.0 Array)   1434080_at (Mouse Genome 430 2.0 Array)   1435070_at (Mouse Genome 430 2.0 Array)   1437743_at (Mouse Genome 430 2.0 Array)   1455616_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125479
Ensembl peptide - ENSMUSP00000032359
Ensembl peptide - ENSMUSP00000084896
Ensembl peptide - ENSMUSP00000092993
Ensembl peptide - ENSMUSP00000123897
Ensembl peptide - ENSMUSP00000124148
NCBI entrez gene - 11569     See in Manteia.
MGI - MGI:1338038
RefSeq - XM_006506909
RefSeq - NM_001005605
RefSeq - NM_001309436
RefSeq - NM_001309437
RefSeq - NM_009637
RefSeq - NM_178803
RefSeq - XM_006506905
RefSeq - XM_006506906
RefSeq Peptide - NP_001005605
RefSeq Peptide - NP_001296365
RefSeq Peptide - NP_848918
RefSeq Peptide - NP_001296366
RefSeq Peptide - NP_033767
swissprot - Q9Z248
swissprot - F6V059
Ensembl - ENSMUSG00000030232
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aebp2ENSDARG00000006038Danio rerio
 AEBP2ENSGALG00000038026Gallus gallus
 AEBP2ENSG00000139154Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003714 transcription corepressor activity IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002926 aganglionic megacolon "extreme dilation of the colon due to defects in innervation from the ganglia, or absence of the ganglia of the myenteric plexus" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003289 abnormal intestinal peristalsis "altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005175 non-pigmented tail tip "lack of color at the end of the tail " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / complex
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / complex






 

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