ENSMUSG00000017548


Mus musculus

Features
Gene ID: ENSMUSG00000017548
  
Biological name :Suz12
  
Synonyms : Polycomb protein Suz12 / Q80U70 / Suz12
  
Possible biological names infered from orthology : Q15022 / SUZ12 polycomb repressive complex 2 subunit
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 79993106
Gene end: 80034123
  
Corresponding Affymetrix probe sets: 10379346 (MoGene1.0st)   1420020_at (Mouse Genome 430 2.0 Array)   1420021_s_at (Mouse Genome 430 2.0 Array)   1427253_s_at (Mouse Genome 430 2.0 Array)   1449661_at (Mouse Genome 430 2.0 Array)   1452364_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017692
Ensembl peptide - ENSMUSP00000126932
Ensembl peptide - ENSMUSP00000128945
Ensembl peptide - ENSMUSP00000129070
NCBI entrez gene - 52615     See in Manteia.
MGI - MGI:1261758
RefSeq - NM_001163018
RefSeq - NM_199196
RefSeq Peptide - NP_001156490
RefSeq Peptide - NP_954666
swissprot - Q80U70
swissprot - E9PW15
swissprot - F6Z494
swissprot - F7B7H9
Ensembl - ENSMUSG00000017548
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0R1D5ENSDARG00000098924Danio rerio
 suz12aENSDARG00000070256Danio rerio
 SUZ12ENSGALG00000003277Gallus gallus
 SUZ12ENSG00000178691Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019135  Polycomb protein, VEFS-Box


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0016571 histone methylation IMP
 biological_processGO:0016574 histone ubiquitination IMP
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0070734 histone H3-K27 methylation IEA
 cellular_componentGO:0001739 sex chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016586 RSC-type complex IBA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0032993 protein-DNA complex IDA
 cellular_componentGO:0035098 ESC/E(Z) complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003723 RNA binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0042054 histone methyltransferase activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046976 histone methyltransferase activity (H3-K27 specific) IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
SUMOylation of chromatin organization proteins
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Suz12Plt8/Suz12+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Suz12tm1Hko/Suz12+
Genetic Background: involves: C57BL/6

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0000777 increased size of inferior colliculus "enlargement of the paired inferior eminence of the mesencephalic tectum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57538]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0000905 increased size of superior colliculus "enlargement of the paired superior eminence of the mesencephalic tectum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57538]
Show

Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

Allelic Composition: Suz12tm1Hko/Suz12tm1Hko
Genetic Background: Not Specified

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12Plt8
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002030 neurofibrosarcoma "malignant neoplasm of fibrous tissue of the nervous system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

Allelic Composition: Suz12tm1Hko/Suz12tm1Hko
Genetic Background: Not Specified

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: C3.MRL-Faslpr/J

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

 MP:0002877 abnormal melanocyte morphology "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Suz12tm1Hko/Suz12+
Genetic Background: involves: C57BL/6

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Suz12tm1Hko/Suz12+
Genetic Background: involves: C57BL/6

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Suz12tm1Hko/Suz12+
Genetic Background: involves: C57BL/6

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko
Genetic Background: B6.Cg-Mtf2tm1.1Hko

Allelic Composition: Mtf2tm1.1Hko/Mtf2tm1.1Hko,Suz12tm1Hko/Suz12+
Genetic Background: involves: C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12+
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Suz12Plt8/Suz12+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005029 abnormal amnion "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Suz12Plt8/Suz12+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009048 enlarged tectum "increased size of the rostral part of the midbrain roof" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Scn1atm1.1Swl/Scn1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JNarl

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010278 increased glioma incidence "greater than the expected number of tumors that arise from glial cells, non-neuronal cells of the nervous tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010310 increased Schwannoma incidence "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; usually associated with a peripheral or cranial nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010314 increased neurofibroma incidence "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; proliferation is disordered and includes portions of nerve fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12Plt8
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

Allelic Composition: Suz12tm1Hko/Suz12tm1Hko
Genetic Background: Not Specified

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Suz12tm1Hko/Suz12tm1Hko
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Mpltm1Wsa/Mpltm1Wsa,Suz12Plt8/Suz12Plt8
Genetic Background: B6.Cg-Mpltm1Wsa Suz12Plt8

 MP:0011199 abnormal amniotic cavity morphology "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

 MP:0011200 abnormal extraembryonic coelom morphology "any structural anomaly of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN:0-12-402035-6, ISBN-10:1405118660]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

 MP:0011202 abnormal ectoplacental cavity morphology "any structural anomaly of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity" [ISBN:0-12-402035-6]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0012710 diastematomyelia "a rare congenital anomaly that results in the splitting of the spinal cord in a longitudinal direction, usually at the level of the upper lumbar vertebra; this condition occurs in the presence of an osseous (bone), cartilaginous or fibrous septum in the central portion of the spinal canal which then produces a complete or incomplete sagittal division of the spinal cord into two hemicords, each half being surrounded by a dural sac; when the split does not reunite distally to the spur, the condition is referred to as a diplomyelia" [MGI:anna]
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Allelic Composition: Drap1tm1Mms/Drap1tm1Mms,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004099 Dnmt1 / P13864 / DNA (cytosine-5)-methyltransferase 1 / P26358* / DNA methyltransferase 1*  / complex / reaction
 ENSMUSG00000020661 Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*  / complex / reaction
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000024193 Phf1 / Q9Z1B8 / PHD finger protein 1 / O43189*  / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction / complex
 ENSMUSG00000029267 Mtf2 / Q02395 / Metal-response element-binding transcription factor 2 / Q9Y483*  / complex
 ENSMUSG00000024240 Epc1 / Q8C9X6 / Enhancer of polycomb homolog 1 / Q9H2F5*  / reaction / complex
 ENSMUSG00000026873 Phf19 / Q9CXG9 / PHD finger protein 19 / Q5T6S3*  / complex
 ENSMUSG00000030232 Aebp2 / Q9Z248 / Zinc finger protein AEBP2 / Q6ZN18* / AE binding protein 2*  / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / complex
 ENSMUSG00000038518 Jarid2 / Q62315 / Protein Jumonji / Q92833* / jumonji and AT-rich interaction domain containing 2*  / complex
 ENSMUSG00000027478 Dnmt3b / O88509 / DNA (cytosine-5)-methyltransferase 3B / Q9UBC3* / DNA methyltransferase 3 beta*  / reaction / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex / reaction






 

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