ENSMUSG00000004099


Mus musculus

Features
Gene ID: ENSMUSG00000004099
  
Biological name :Dnmt1
  
Synonyms : DNA (cytosine-5)-methyltransferase 1 / Dnmt1 / P13864
  
Possible biological names infered from orthology : DNA methyltransferase 1 / P26358
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 20907209
Gene end: 20959888
  
Corresponding Affymetrix probe sets: 10591369 (MoGene1.0st)   1422946_a_at (Mouse Genome 430 2.0 Array)   1435122_x_at (Mouse Genome 430 2.0 Array)   1447877_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004202
Ensembl peptide - ENSMUSP00000136669
Ensembl peptide - ENSMUSP00000136982
Ensembl peptide - ENSMUSP00000150433
NCBI entrez gene - 13433     See in Manteia.
MGI - MGI:94912
RefSeq - XM_011242393
RefSeq - NM_001199431
RefSeq - NM_001199432
RefSeq - NM_001199433
RefSeq - NM_001314011
RefSeq - NM_010066
RefSeq - XM_006509988
RefSeq Peptide - NP_034196
RefSeq Peptide - NP_001186362
RefSeq Peptide - NP_001300940
RefSeq Peptide - NP_001186361
RefSeq Peptide - NP_001186360
swissprot - J3QNW0
swissprot - P13864
Ensembl - ENSMUSG00000004099
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnmt1ENSDARG00000030756Danio rerio
 DNMT1ENSG00000130816Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR001525  C-5 cytosine methyltransferase
 IPR002857  Zinc finger, CXXC-type
 IPR010506  DMAP1-binding domain
 IPR017198  DNA (cytosine-5)-methyltransferase 1-like
 IPR018117  DNA methylase, C-5 cytosine-specific, active site
 IPR022702  DNA (cytosine-5)-methyltransferase 1, replication foci domain
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR031303  DNA methylase, C-5 cytosine-specific, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006306 DNA methylation IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007265 Ras protein signal transduction ISS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010216 maintenance of DNA methylation IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0016458 gene silencing IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032776 DNA methylation on cytosine IMP
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0043045 DNA methylation involved in embryo development IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation ISO
 biological_processGO:0051573 negative regulation of histone H3-K9 methylation ISO
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0090116 C-5 methylation of cytosine IEA
 biological_processGO:0090309 positive regulation of methylation-dependent chromatin silencing ISO
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005721 pericentric heterochromatin IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003886 DNA (cytosine-5-)-methyltransferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IDA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0008327 methyl-CpG binding IDA
 molecular_functionGO:0009008 DNA-methyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates TAS
 molecular_functionGO:1990841 promoter-specific chromatin binding ISS


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
SUMOylation of DNA methylation proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Dnmt1tm2Enl/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dnmt1tm1Okan/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Dnmt1tm2Enl/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dnmt1tm1Okan/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Sgpl1tm1.2Npa/Sgpl1tm1.2Npa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
Show

Allelic Composition: Dnmt1tm2Enl/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dnmt1tm1Okan/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Dnmt1tm1Enl/Dnmt1tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dnmt1tm2Enl/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dnmt1tm1Okan/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Dnmt1tm1Jrc/Dnmt1tm1Jrc
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Dnmt1tm1Pwl/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1tm1Pwl,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnmt1tm2Enl/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dnmt1tm1Pwl/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Dnmt1tm2Jae/Dnmt1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dnmt1tm1Pwl/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0003121 genomic imprinting "phenotype resulting from inactivation of specific loci during gametogenesis, but not encoded by the DNA itself" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac2Gt(W035F03)Joe/Hdac2Gt(W035F03)Joe,Tg(Myh6-Hod)3Joe/?
Genetic Background: Not Specified

 MP:0003136 yellow coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is increased compared to wild-type agouti" [llw2:Linda L. Washburn, Mouse Genome Informatics Curator]
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Allelic Composition: Avy/A,Smchd1MommeD1/Smchd1+
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0003787 abnormal imprinting "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Dnmt1tm1Jrc/Dnmt1tm1Jrc
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmap1tm1.2Jrc/Dmap1tm1.2Jrc,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnmt1tm2Enl/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dnmt1tm1Okan/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnmt1tm1Enl/Dnmt1tm1Enl
Genetic Background: involves: 129S4/SvJae

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Achetm1Loc/Achetm1Loc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: ApcMin/Apc+,Dnmt1tm1Jae/Dnmt1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Dnmt1tm1Enl/Dnmt1tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dnmt1tm2Enl/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dnmt1tm1Enl/Dnmt1tm1Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnmt1tm2Enl/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Dnmt1tm1Enl/Dnmt1tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dnmt1tm2Enl/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Dmap1tm1.2Jrc/Dmap1tm1.2Jrc,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Avy/A,Smchd1MommeD1/Smchd1+
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Avy/A,Smchd1MommeD1/Smchd1+
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0012131 small visceral yolk sac "reduced size of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo" [MGI:anna]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Dnmt1tm1Pwl/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1tm1Pwl,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001228 Uhrf1 / Q8VDF2 / ubiquitin-like, containing PHD and RING finger domains, 1 / Q96T88* / ubiquitin like with PHD and ring finger domains 1*  / reaction / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex / reaction






 

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