ENSDARG00000030756


Danio rerio

Features
Gene ID: ENSDARG00000030756
  
Biological name :dnmt1
  
Synonyms : DNA (cytosine-5-)-methyltransferase 1 / dnmt1
  
Possible biological names infered from orthology : DNA methyltransferase 1 / P13864 / P26358
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 54591218
Gene end: 54607166
  
Corresponding Affymetrix probe sets: Dr.25162.1.S1_at (Zebrafish Array)   NM_131189_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000013243
NCBI entrez gene - 30430     See in Manteia.
RefSeq - NM_131189
RefSeq - XM_017353152
RefSeq Peptide - NP_571264
swissprot - F1RCN0
ZFIN ID - ZDB-GENE-990714-15
Ensembl - ENSDARG00000030756
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DNMT1ENSG00000130816Homo sapiens
 Dnmt1ENSMUSG00000004099Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR001525  C-5 cytosine methyltransferase
 IPR002857  Zinc finger, CXXC-type
 IPR010506  DMAP1-binding domain
 IPR017198  DNA (cytosine-5)-methyltransferase 1-like
 IPR018117  DNA methylase, C-5 cytosine-specific, active site
 IPR022702  DNA (cytosine-5)-methyltransferase 1, replication foci domain
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR031303  DNA methylase, C-5 cytosine-specific, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0006306 DNA methylation IMP
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032776 DNA methylation on cytosine IMP
 biological_processGO:0035622 intrahepatic bile duct development IMP
 biological_processGO:0044030 regulation of DNA methylation IMP
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0051567 histone H3-K9 methylation IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0090116 C-5 methylation of cytosine IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003886 DNA (cytosine-5-)-methyltransferase activity IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
SUMOylation of DNA methylation proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta hematopoietic stem cell amount , ameliorated
Show

 ZFA:0000035 lens lens morphology , abnormal
lens structure , abnormal
lens degenerate , abnormal
lens poorly differentiated , abnormal
lens protruding , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
liver hypoplastic , abnormal
Show

 ZFA:0000140 pancreas pancreas decreased distribution , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium dorsal region aplastic , abnormal
retinal pigmented epithelium dorsal region absent , abnormal
Show

 ZFA:0000152 retina retina disorganized , abnormal
Show

 ZFA:0000208 gall bladder gall bladder decreased functionality , abnormal
Show

 ZFA:0001078 thymus thymus lymphocyte absent , abnormal
Show

 ZFA:0001094 whole organism whole organism morphology , abnormal
Show

 ZFA:0001114 head head morphology , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton aplastic , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas decreased size , abnormal
exocrine pancreas aplastic , abnormal
exocrine pancreas undifferentiated , abnormal
exocrine pancreas hypoplastic , abnormal
exocrine pancreas nucleus condensed , abnormal
Show

 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton aplastic , abnormal
Show

 ZFA:0001326 lens epithelium lens epithelium structure , abnormal
Show

 ZFA:0005023 hematopoietic system hematopoietic system posterior region decreased distribution , abnormal
hematopoietic system posterior region spatial pattern , ameliorated
Show

 ZFA:0005123 gut epithelium gut epithelium morphology , abnormal
gut epithelium flattened , abnormal
Show

 ZFA:0005124 intestinal epithelium intestinal epithelium undifferentiated , abnormal
intestinal epithelium gut endothelial cell absent , abnormal
Show

 ZFA:0005164 bile ductule bile ductule degenerate , abnormal
bile ductule morphology , abnormal
bile ductule morphology , ameliorated
Show

 ZFA:0005169 intrahepatic bile duct intrahepatic bile duct decreased branchiness , abnormal
Show

 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased distribution , abnormal
hematopoietic stem cell spatial pattern , ameliorated
Show

 ZFA:0009111 hepatocyte hepatocyte mislocalised , abnormal
hepatocyte degenerate , abnormal
hepatocyte mislocalised posteriorly , abnormal
hepatocyte increased size , abnormal
hepatocyte aggregated , abnormal
hepatocyte decreased distribution , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased distribution , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell morphology , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell morphology , abnormal
Show

 ZFA:0009324 myeloid cell myeloid cell increased amount , abnormal
myeloid cell decreased amount , abnormal
myeloid cell decreased distribution , abnormal
Show

 ZFA:0009399 intestinal epithelial cell intestinal epithelial cell decreased height , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000098924 suz12b / B0R1D5 / SUZ12 polycomb repressive complex 2b subunit / SUZ12* / Q80U70* / Q15022* / Polycomb protein Suz12 * / SUZ12 polycomb repressive complex 2 subunit*  / complex / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000105345 zgc:173552  / complex / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000099640 eed / Q566T0 / embryonic ectoderm development / O75530* / Q921E6* / Polycomb protein EED *  / reaction / complex
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / complex / reaction
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / complex / reaction






 

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