ENSMUSG00000001228


Mus musculus

Features
Gene ID: ENSMUSG00000001228
  
Biological name :Uhrf1
  
Synonyms : Q8VDF2 / ubiquitin-like, containing PHD and RING finger domains, 1 / Uhrf1
  
Possible biological names infered from orthology : Q96T88 / ubiquitin like with PHD and ring finger domains 1
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: D
Gene start: 56303321
Gene end: 56323486
  
Corresponding Affymetrix probe sets: 10446074 (MoGene1.0st)   1415810_at (Mouse Genome 430 2.0 Array)   1415811_at (Mouse Genome 430 2.0 Array)   1439227_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108658
Ensembl peptide - ENSMUSP00000108662
Ensembl peptide - ENSMUSP00000125830
Ensembl peptide - ENSMUSP00000001258
Ensembl peptide - ENSMUSP00000108661
NCBI entrez gene - 18140     See in Manteia.
MGI - MGI:1338889
RefSeq - XM_006523800
RefSeq - NM_001111078
RefSeq - NM_001111079
RefSeq - NM_001111080
RefSeq - NM_010931
RefSeq - XM_006523799
RefSeq Peptide - NP_001104549
RefSeq Peptide - NP_001104550
RefSeq Peptide - NP_035061
RefSeq Peptide - NP_001104548
swissprot - Q8VDF2
swissprot - E9Q5Y5
Ensembl - ENSMUSG00000001228
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uhrf1ENSDARG00000103409Danio rerio
 UHRF1ENSGALG00000034271Gallus gallus
 UHRF1ENSG00000276043Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Uhrf2 / Q7TMI3 / ubiquitin-like, containing PHD and RING finger domains 2 / Q96PU4* / ubiquitin like with PHD and ring finger domains 2*ENSMUSG0000002481754


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003105  SRA-YDG
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014722  Ribosomal protein L2, domain 2
 IPR015947  PUA-like superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR019956  Ubiquitin
 IPR021991  UHRF1, tandem tudor domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR036987  SRA-YDG superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010216 maintenance of DNA methylation IMP
 biological_processGO:0010390 histone monoubiquitination IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016574 histone ubiquitination ISS
 biological_processGO:0032270 positive regulation of cellular protein metabolic process ISO
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0090308 regulation of methylation-dependent chromatin silencing IBA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0000791 euchromatin ISO
 cellular_componentGO:0000792 heterochromatin ISO
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0016363 nuclear matrix IDA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0008327 methyl-CpG binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031493 nucleosomal histone binding IDA
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0042393 histone binding ISS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044729 hemi-methylated DNA-binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006029 abnormal sclerotome "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006346 small branchial arch "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000004099 Dnmt1 / P13864 / DNA (cytosine-5)-methyltransferase 1 / P26358* / DNA methyltransferase 1*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction






 

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