ENSDARG00000103409


Danio rerio

Features
Gene ID: ENSDARG00000103409
  
Biological name :uhrf1
  
Synonyms : E7EZF3 / ubiquitin-like with PHD and ring finger domains 1 / uhrf1
  
Possible biological names infered from orthology : Q8VDF2 / Q96T88 / ubiquitin-like, containing PHD and RING finger domains, 1
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 4408643
Gene end: 4439311
  
Corresponding Affymetrix probe sets: Dr.18169.1.S1_at (Zebrafish Array)   Dr.9809.2.S1_at (Zebrafish Array)   NM_213077_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000135054
NCBI entrez gene - 406350     See in Manteia.
RefSeq - NM_213077
RefSeq Peptide - NP_998242
swissprot - E7EZF3
ZFIN ID - ZDB-GENE-040426-2039
Ensembl - ENSDARG00000103409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UHRF1ENSGALG00000034271Gallus gallus
 UHRF1ENSG00000276043Homo sapiens
 Uhrf1ENSMUSG00000001228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003105  SRA-YDG
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014722  Ribosomal protein L2, domain 2
 IPR015947  PUA-like superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR021991  UHRF1, tandem tudor domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001889 liver development IMP
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010216 maintenance of DNA methylation IMP
 biological_processGO:0010390 histone monoubiquitination IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016574 histone ubiquitination ISS
 biological_processGO:0031100 animal organ regeneration IMP
 biological_processGO:0044027 hypermethylation of CpG island IMP
 biological_processGO:0051865 protein autoubiquitination ISS
 biological_processGO:0060729 intestinal epithelial structure maintenance IMP
 biological_processGO:0090308 regulation of methylation-dependent chromatin silencing IBA
 cellular_componentGO:0000790 nuclear chromatin ISS
 cellular_componentGO:0000791 euchromatin ISS
 cellular_componentGO:0000792 heterochromatin ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005657 replication fork ISS
 cellular_componentGO:0005720 nuclear heterochromatin IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035064 methylated histone binding ISS
 molecular_functionGO:0042393 histone binding ISS
 molecular_functionGO:0044729 hemi-methylated DNA-binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens quality , abnormal
lens morphology , abnormal
lens mislocalised , abnormal
lens degenerate , abnormal
lens opaque , abnormal
lens protruding , abnormal
Show

 ZFA:0000084 yolk yolk increased size , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye morphology , abnormal
Show

 ZFA:0000112 gut gut quality , abnormal
gut morphology , abnormal
gut hypoplastic , abnormal
gut decreased size , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
liver quality , abnormal
liver apoptotic process increased process quality , abnormal
liver cell cycle arrested , abnormal
liver morphology , abnormal
liver regenerating tissue hypoplastic , abnormal
Show

 ZFA:0000217 inner ear inner ear cell death increased process quality , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased life span , abnormal
whole organism lethal (sensu genetics) , abnormal
Show

 ZFA:0001114 head head morphology , abnormal
head cell death increased process quality , abnormal
head decreased size , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton cell death increased process quality , abnormal
mandibular arch skeleton morphology , abnormal
Show

 ZFA:0001283 pupil pupil decreased size , abnormal
Show

 ZFA:0001338 intestine intestine has extra parts of type neutrophil , abnormal
intestine neutrophil increased amount , abnormal
Show

 ZFA:0005123 gut epithelium gut epithelium morphology , abnormal
gut epithelium permeability , abnormal
gut epithelium flattened , abnormal
gut epithelium brush border decreased size , abnormal
Show

 ZFA:0005574 lens capsule lens capsule absent , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte nucleus increased size , abnormal
hepatocyte DNA methylation decreased process quality , abnormal
hepatocyte apoptotic , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell morphology , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell morphology , abnormal
Show

 ZFA:0009399 intestinal epithelial cell intestinal epithelial cell cuboid , abnormal
intestinal epithelial cell DNA methylation decreased process quality , abnormal
intestinal epithelial cell apoptotic process increased process quality , abnormal
intestinal epithelial cell decreased height , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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