ENSMUSG00000024817


Mus musculus

Features
Gene ID: ENSMUSG00000024817
  
Biological name :Uhrf2
  
Synonyms : Q7TMI3 / ubiquitin-like, containing PHD and RING finger domains 2 / Uhrf2
  
Possible biological names infered from orthology : Q96PU4 / ubiquitin like with PHD and ring finger domains 2
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 30030513
Gene end: 30093722
  
Corresponding Affymetrix probe sets: 10462454 (MoGene1.0st)   1447217_at (Mouse Genome 430 2.0 Array)   1454920_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025739
Ensembl peptide - ENSMUSP00000108171
NCBI entrez gene - 109113     See in Manteia.
MGI - MGI:1923718
RefSeq - XM_006526603
RefSeq - NM_144873
RefSeq - XM_006526602
RefSeq Peptide - NP_659122
swissprot - Q7TMI3
swissprot - Q3T995
Ensembl - ENSMUSG00000024817
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UHRF2ENSGALG00000015052Gallus gallus
 UHRF2ENSG00000147854Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Uhrf1 / Q8VDF2 / ubiquitin-like, containing PHD and RING finger domains, 1 / Q96T88* / ubiquitin like with PHD and ring finger domains 1*ENSMUSG0000000122852


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003105  SRA-YDG
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014722  Ribosomal protein L2, domain 2
 IPR015947  PUA-like superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR021991  UHRF1, tandem tudor domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR036987  SRA-YDG superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0010216 maintenance of DNA methylation IBA
 biological_processGO:0016567 protein ubiquitination ISS
 biological_processGO:0030154 cell differentiation ISS
 biological_processGO:0051865 protein autoubiquitination ISS
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0090308 regulation of methylation-dependent chromatin silencing IBA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ube2ctm1.1(KOMP)Wtsi/Ube2c+
Genetic Background: C57BL/6N-Ube2ctm1.1(KOMP)Wtsi/J

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0003795 abnormal bone structure 
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gfi1tm1(cre)Gan/Gfi1+,Rfx1tm1.1Wrth/Rfx1tm1.1Wrth,Rfx3tm2Wrth/Rfx3tm2Wrth
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Gfi1tm1(cre)Gan/Gfi1+,Rfx1tm1.1Wrth/Rfx1tm1.1Wrth,Rfx3tm2Wrth/Rfx3tm2Wrth
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gfi1tm1(cre)Gan/Gfi1+,Rfx1tm1.1Wrth/Rfx1tm1.1Wrth,Rfx3tm2Wrth/Rfx3tm2Wrth
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0010506 prolonged RR interval "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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