ENSDARG00000010571


Danio rerio

Features
Gene ID: ENSDARG00000010571
  
Biological name :ezh2
  
Synonyms : enhancer of zeste 2 polycomb repressive complex 2 subunit / ezh2
  
Possible biological names infered from orthology : Histone-lysine N-methyltransferase EZH2 / Q15910 / Q61188
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 17345521
Gene end: 17364456
  
Corresponding Affymetrix probe sets: Dr.18898.1.S1_at (Zebrafish Array)   Dr.24749.1.S1_at (Zebrafish Array)   Dr.3788.1.A1_at (Zebrafish Array)   NM_001077279_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000023693
Ensembl peptide - ENSDARP00000129785
Ensembl peptide - ENSDARP00000143882
NCBI entrez gene - 768133     See in Manteia.
RefSeq - NM_001077279
RefSeq Peptide - NP_001070747
swissprot - F1QQ58
swissprot - A0A286Y9P9
swissprot - X1WHS1
ZFIN ID - ZDB-GENE-041111-259
Ensembl - ENSDARG00000010571
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EZH2ENSGALG00000043399Gallus gallus
 EZH2ENSG00000106462Homo sapiens
 Ezh2ENSMUSG00000029687Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ehmt1b / euchromatic histone-lysine N-methyltransferase 1b / EHMT1* / Q5DW34* / Q9H9B1* / Histone-lysine N-methyltransferase EHMT1 * / euchromatic histone lysine methyltransferase 1*ENSDARG0000002663416
ehmt2 / euchromatic histone-lysine N-methyltransferase 2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*ENSDARG0000010232515
nsd1a / nuclear receptor binding SET domain protein 1a / NSD1* / Q96L73* / nuclear receptor binding SET domain protein 1*ENSDARG0000006001614
nsd3 / nuclear receptor binding SET domain protein 3 / Q6P2L6* / Q9BZ95* / Histone-lysine N-methyltransferase NSD3 *ENSDARG0000006276514
nsd1b / nuclear receptor binding SET domain protein 1b / NSD1* / Q96L73* / nuclear receptor binding SET domain protein 1*ENSDARG0000006070514
ehmt1a / euchromatic histone-lysine N-methyltransferase 1a / EHMT1* / Q5DW34* / Q9H9B1* / Histone-lysine N-methyltransferase EHMT1 * / euchromatic histone lysine methyltransferase 1*ENSDARG0000006815713
ash1l / ash1 (absent, small, or homeotic)-like (Drosophila) / Q99MY8* / Q9NR48* / Histone-lysine N-methyltransferase ASH1L * / ASH1 like histone lysine methyltransferase*ENSDARG0000007098113
nsd2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *ENSDARG0000002622513
setd2 / SET domain containing 2 / E9Q5F9* / Q9BYW2* / Histone-lysine N-methyltransferase SETD2 *ENSDARG0000006224412
setdb1b / SET domain, bifurcated 1b / Q15047* / SETDB1* / SET domain bifurcated 1*ENSDARG0000009902112
Q6DGD3 / suv39h1a / suppressor of variegation 3-9 homolog 1a / O54864* / O43463* / SUV39H1* / suppressor of variegation 3-9 1* / suppressor of variegation 3-9 homolog 1*ENSDARG0000002679911
Q1L8U8 / setdb1a / SET domain, bifurcated 1aENSDARG0000004124311
suv39h1b / suppressor of variegation 3-9 homolog 1b / O54864* / O43463* / SUV39H1* / suppressor of variegation 3-9 1* / suppressor of variegation 3-9 homolog 1*ENSDARG0000005575311
ezh1 / enhancer of zeste 1 polycomb repressive complex 2 subunitENSDARG000000378949
setbp1 / SET binding protein 1 / Q9Y6X0* / Q9Z180* / SET-binding protein *ENSDARG000000937998
setmar / SET domain and mariner transposase fusion gene / Q53H47* / Q80UJ9* / Histone-lysine N-methyltransferase SETMAR *ENSDARG000000748368


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR001214  SET domain
 IPR021654  Histone-lysine N-methyltransferase EZH1/EZH2
 IPR026489  CXC domain
 IPR033467  Tesmin/TSO1-like CXC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0034968 histone lysine methylation IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation extension , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
cardiac ventricle decreased amount , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary absent , abnormal
Show

 ZFA:0000075 spinal cord spinal cord regeneration process quality , abnormal
Show

 ZFA:0000107 eye eye mislocalised , abnormal
eye decreased size , abnormal
Show

 ZFA:0000112 gut gut morphology , abnormal
gut straight , abnormal
Show

 ZFA:0000114 heart heart straight , abnormal
heart morphology , abnormal
heart decreased size , abnormal
heart wholeness , abnormal
heart edematous , abnormal
heart decreased distribution , abnormal
heart anatomical region mislocalised , abnormal
Show

 ZFA:0000123 liver liver absent , abnormal
Show

 ZFA:0000135 notochord notochord mislocalised , abnormal
Show

 ZFA:0000140 pancreas pancreas cell apoptotic , abnormal
Show

 ZFA:0000360 heart tube heart tube anatomical region mislocalised , abnormal
Show

 ZFA:0000471 atrium atrium decreased amount , abnormal
Show

 ZFA:0000823 rhombomere 5 rhombomere 5 decreased amount , abnormal
Show

 ZFA:0000948 rhombomere 3 rhombomere 3 decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism posterior region increased distribution , abnormal
whole organism absent , abnormal
whole organism dead , abnormal
whole organism decreased life span , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin absent , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas absent , abnormal
exocrine pancreas decreased size , abnormal
exocrine pancreas decreased amount , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch artery absent , abnormal
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal anatomical region mislocalised , abnormal
Show

 ZFA:0001319 myocardium myocardium decreased amount , abnormal
Show

 ZFA:0001320 endocardium endocardium decreased amount , abnormal
Show

 ZFA:0001338 intestine intestine cell apoptotic , abnormal
Show

 ZFA:0001718 presumptive atrium heart tube presumptive atrium heart tube anatomical region mislocalised , abnormal
Show

 ZFA:0001719 presumptive cardiac ventricle heart tube presumptive cardiac ventricle heart tube decreased amount , abnormal
presumptive cardiac ventricle heart tube anatomical region mislocalised , abnormal
Show

 ZFA:0005124 intestinal epithelium intestinal epithelium morphology , abnormal
Show

 ZFA:0005126 intestinal bulb epithelium intestinal bulb epithelium morphology , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell detached from cardiac ventricle , abnormal
cardiac muscle cell detached from atrium , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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