ENSDARG00000102325


Danio rerio

Features
Gene ID: ENSDARG00000102325
  
Biological name :ehmt2
  
Synonyms : ehmt2 / euchromatic histone-lysine N-methyltransferase 2
  
Possible biological names infered from orthology : euchromatic histone lysine methyltransferase 2 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7 / Q9Z148
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 981321
Gene end: 1002959
  
Corresponding Affymetrix probe sets: Dr.1988.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000130049
swissprot - A0A0G2KCN9
ZFIN ID - ZDB-GENE-010501-6
Ensembl - ENSDARG00000102325
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EHMT2ENSG00000204371Homo sapiens
 Ehmt2ENSMUSG00000013787Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ehmt1b / euchromatic histone-lysine N-methyltransferase 1b / EHMT1* / Q5DW34* / Q9H9B1* / Histone-lysine N-methyltransferase EHMT1 * / euchromatic histone lysine methyltransferase 1*ENSDARG0000002663439
ehmt1a / euchromatic histone-lysine N-methyltransferase 1a / EHMT1* / Q5DW34* / Q9H9B1* / Histone-lysine N-methyltransferase EHMT1 * / euchromatic histone lysine methyltransferase 1*ENSDARG0000006815733
nsd3 / nuclear receptor binding SET domain protein 3 / Q6P2L6* / Q9BZ95* / Histone-lysine N-methyltransferase NSD3 *ENSDARG0000006276511
setdb1b / SET domain, bifurcated 1b / Q15047* / SETDB1* / SET domain bifurcated 1*ENSDARG0000009902111
nsd1a / nuclear receptor binding SET domain protein 1a / NSD1* / Q96L73* / nuclear receptor binding SET domain protein 1*ENSDARG0000006001611
nsd2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *ENSDARG0000002622510
Q1L8U8 / setdb1a / SET domain, bifurcated 1aENSDARG0000004124310
ezh2 / enhancer of zeste 2 polycomb repressive complex 2 subunit / Q15910* / Q61188* / Histone-lysine N-methyltransferase EZH2 *ENSDARG0000001057110
nsd1b / nuclear receptor binding SET domain protein 1b / NSD1* / Q96L73* / nuclear receptor binding SET domain protein 1*ENSDARG0000006070510
ash1l / ash1 (absent, small, or homeotic)-like (Drosophila) / Q99MY8* / Q9NR48* / Histone-lysine N-methyltransferase ASH1L * / ASH1 like histone lysine methyltransferase*ENSDARG000000709819
setd2 / SET domain containing 2 / E9Q5F9* / Q9BYW2* / Histone-lysine N-methyltransferase SETD2 *ENSDARG000000622449
Q6DGD3 / suv39h1a / suppressor of variegation 3-9 homolog 1a / O54864* / O43463* / SUV39H1* / suppressor of variegation 3-9 1* / suppressor of variegation 3-9 homolog 1*ENSDARG000000267998
suv39h1b / suppressor of variegation 3-9 homolog 1b / O54864* / O43463* / SUV39H1* / suppressor of variegation 3-9 1* / suppressor of variegation 3-9 homolog 1*ENSDARG000000557538
setmar / SET domain and mariner transposase fusion gene / Q53H47* / Q80UJ9* / Histone-lysine N-methyltransferase SETMAR *ENSDARG000000748367
setbp1 / SET binding protein 1 / Q9Y6X0* / Q9Z180* / SET-binding protein *ENSDARG000000937995
ezh1 / enhancer of zeste 1 polycomb repressive complex 2 subunitENSDARG000000378940


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR002110  Ankyrin repeat
 IPR007728  Pre-SET domain
 IPR020683  Ankyrin repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0022008 neurogenesis IGI
 biological_processGO:0031017 exocrine pancreas development IGI
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0051570 regulation of histone H3-K9 methylation IGI
 biological_processGO:0060219 camera-type eye photoreceptor cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Senescence-Associated Secretory Phenotype (SASP)
Regulation of TP53 Activity through Methylation
RNA Polymerase I Transcription Initiation
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000128 midbrain midbrain morphology , abnormal
midbrain apoptotic process increased occurrence , abnormal
midbrain decreased amount , abnormal
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 ZFA:0000152 retina retina increased amount , abnormal
retina apoptotic process increased occurrence , abnormal
retina nucleus decreased amount , abnormal
retina cell proliferation increased occurrence , abnormal
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 ZFA:0009255 amacrine cell amacrine cell absent , abnormal
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 ZFA:0009262 retinal cone cell retinal cone cell absent , abnormal
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 ZFA:0009318 retinal bipolar neuron retinal bipolar neuron absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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