ENSG00000204371


Homo sapiens

Features
Gene ID: ENSG00000204371
  
Biological name :EHMT2
  
Synonyms : EHMT2 / euchromatic histone lysine methyltransferase 2 / Q96KQ7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.33
Gene start: 31879759
Gene end: 31897687
  
Corresponding Affymetrix probe sets: 202326_at (Human Genome U133 Plus 2.0 Array)   207484_s_at (Human Genome U133 Plus 2.0 Array)   229079_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000412353
Ensembl peptide - ENSP00000364678
Ensembl peptide - ENSP00000364680
Ensembl peptide - ENSP00000364687
Ensembl peptide - ENSP00000379078
NCBI entrez gene - 10919     See in Manteia.
OMIM - 604599
RefSeq - XM_017010202
RefSeq - NM_001289413
RefSeq - NM_001318833
RefSeq - NM_006709
RefSeq - NM_025256
RefSeq - XM_005248824
RefSeq - XM_006714974
RefSeq - XM_006714975
RefSeq - XM_006714976
RefSeq Peptide - NP_001276342
RefSeq Peptide - NP_006700
RefSeq Peptide - NP_079532
RefSeq Peptide - NP_001305762
swissprot - Q96KQ7
swissprot - A0A024RCN9
swissprot - A2ABF9
swissprot - A2ABF8
swissprot - H0Y4K5
Ensembl - ENSG00000204371
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ehmt2ENSDARG00000102325Danio rerio
 Ehmt2ENSMUSG00000013787Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1ENSG0000018109046
NSD1 / Q96L73 / nuclear receptor binding SET domain protein 1ENSG0000016567114
NSD2 / O96028 / nuclear receptor binding SET domain protein 2ENSG0000010968512
Q15047 / SETDB1 / SET domain bifurcated 1ENSG0000014337912
ASH1L / Q9NR48 / ASH1 like histone lysine methyltransferaseENSG0000011653911
SETD2 / Q9BYW2 / SET domain containing 2ENSG0000018155511
NSD3 / Q9BZ95 / nuclear receptor binding SET domain protein 3ENSG0000014754811
EZH1 / Q92800 / enhancer of zeste 1 polycomb repressive complex 2 subunitENSG0000010879910
EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunitENSG0000010646210
O43463 / SUV39H1 / suppressor of variegation 3-9 homolog 1ENSG000001019459
Q9Y6X0 / SETBP1 / SET binding protein 1ENSG000001522179
Q96T68 / SETDB2 / SET domain bifurcated 2ENSG000001361699
Q9H5I1 / SUV39H2 / suppressor of variegation 3-9 homolog 2ENSG000001524558
Q53H47 / SETMAR / SET domain and mariner transposase fusion geneENSG000001703646


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR002110  Ankyrin repeat
 IPR007728  Pre-SET domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006275 regulation of DNA replication IMP
 biological_processGO:0006306 DNA methylation ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007130 synaptonemal complex assembly IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0009566 fertilization IEA
 biological_processGO:0010424 DNA methylation on cytosine within a CG sequence IEA
 biological_processGO:0016571 histone methylation IMP
 biological_processGO:0018027 peptidyl-lysine dimethylation IDA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0035265 organ growth IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0036166 phenotypic switching IEA
 biological_processGO:0044030 regulation of DNA methylation IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0048665 neuron fate specification IEA
 biological_processGO:0051567 histone H3-K9 methylation IEA
 biological_processGO:0051569 regulation of histone H3-K4 methylation IEA
 biological_processGO:0051570 regulation of histone H3-K9 methylation IEA
 biological_processGO:0060992 response to fungicide IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 biological_processGO:0070734 histone H3-K27 methylation IEA
 biological_processGO:0071314 cellular response to cocaine IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1902902 negative regulation of autophagosome assembly IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046974 histone methyltransferase activity (H3-K9 specific) ISS
 molecular_functionGO:0046976 histone methyltransferase activity (H3-K27 specific) ISS
 molecular_functionGO:0070742 C2H2 zinc finger domain binding IPI
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
Senescence-Associated Secretory Phenotype (SASP)
PKMTs methylate histone lysines
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Regulation of TP53 Activity through Methylation
RNA Polymerase I Transcription Initiation
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100395 Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit  / reaction / complex
 ENSG00000105325 FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1  / reaction / complex
 ENSG00000156374 PCGF6 / Q9BYE7 / polycomb group ring finger 6  / complex / reaction
 ENSG00000125482 TTF1 / Q15361 / transcription termination factor 1  / complex / reaction
 ENSG00000015153 YAF2 / Q8IY57 / YY1 associated factor 2  / reaction / complex
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / complex
 ENSG00000121481 RNF2 / Q99496 / ring finger protein 2  / complex / reaction
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / complex / reaction
 ENSG00000125952 MAX / P61244 / MYC associated factor X  / complex / reaction
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / reaction / complex
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / reaction / complex
 ENSG00000225830 ERCC6 / P0DP91 / Q03468 / Q8N328 / ERCC excision repair 6, chromatin remodeling factor  / reaction / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction
 ENSG00000174197 MGA / Q8IWI9 / MGA, MAX dimerization protein  / complex / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000122565 CBX3 / Q13185 / chromobox 3  / reaction / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction






 

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