ENSG00000122565


Homo sapiens

Features
Gene ID: ENSG00000122565
  
Biological name :CBX3
  
Synonyms : CBX3 / chromobox 3 / Q13185
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p15.2
Gene start: 26201162
Gene end: 26213356
  
Corresponding Affymetrix probe sets: 1555920_at (Human Genome U133 Plus 2.0 Array)   200037_s_at (Human Genome U133 Plus 2.0 Array)   201091_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000336687
Ensembl peptide - ENSP00000473748
Ensembl peptide - ENSP00000408672
Ensembl peptide - ENSP00000387348
Ensembl peptide - ENSP00000379670
NCBI entrez gene - 11335     See in Manteia.
OMIM - 604477
RefSeq - XM_005249611
RefSeq - NM_007276
RefSeq - NM_016587
RefSeq Peptide - NP_057671
RefSeq Peptide - NP_009207
swissprot - B8ZZ43
swissprot - S4R2Y4
swissprot - Q13185
swissprot - A4D177
swissprot - C9JMM0
Ensembl - ENSG00000122565
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbx3aENSDARG00000003860Danio rerio
 cbx3bENSDARG00000092158Danio rerio
 CBX3ENSGALG00000011038Gallus gallus
 Cbx3ENSMUSG00000029836Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CBX1 / P83916 / chromobox 1ENSG0000010846872
CBX5 / P45973 / chromobox 5ENSG0000009491663


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR008251  Chromo shadow domain
 IPR016197  Chromo-like domain superfamily
 IPR017984  Chromo domain subgroup
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0000775 chromosome, centromeric region IDA
 cellular_componentGO:0000779 condensed chromosome, centromeric region ISS
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope ISS
 cellular_componentGO:0005637 nuclear inner membrane NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0031618 nuclear pericentric heterochromatin ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:1990226 histone methyltransferase binding IPI


Pathways (from Reactome)
Pathway description
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
RNA Polymerase I Chain Elongation
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100395 Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit  / reaction / complex
 ENSG00000174197 MGA / Q8IWI9 / MGA, MAX dimerization protein  / reaction / complex
 ENSG00000125952 MAX / P61244 / MYC associated factor X  / reaction / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / complex / reaction
 ENSG00000156374 PCGF6 / Q9BYE7 / polycomb group ring finger 6  / complex / reaction
 ENSG00000015153 YAF2 / Q8IY57 / YY1 associated factor 2  / complex / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex / reaction
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / complex / reaction
 ENSG00000121481 RNF2 / Q99496 / ring finger protein 2  / complex / reaction
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / complex / reaction
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / reaction / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction / complex






 

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