ENSG00000094916


Homo sapiens

Features
Gene ID: ENSG00000094916
  
Biological name :CBX5
  
Synonyms : CBX5 / chromobox 5 / P45973
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.13
Gene start: 54230940
Gene end: 54280133
  
Corresponding Affymetrix probe sets: 209715_at (Human Genome U133 Plus 2.0 Array)   212126_at (Human Genome U133 Plus 2.0 Array)   226085_at (Human Genome U133 Plus 2.0 Array)   230752_at (Human Genome U133 Plus 2.0 Array)   231862_at (Human Genome U133 Plus 2.0 Array)   234990_at (Human Genome U133 Plus 2.0 Array)   241875_at (Human Genome U133 Plus 2.0 Array)   242069_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000209875
Ensembl peptide - ENSP00000401009
Ensembl peptide - ENSP00000449207
Ensembl peptide - ENSP00000450190
NCBI entrez gene - 23468     See in Manteia.
OMIM - 604478
RefSeq - NM_001127321
RefSeq - NM_001127322
RefSeq - NM_012117
RefSeq Peptide - NP_001120793
RefSeq Peptide - NP_001120794
RefSeq Peptide - NP_036249
swissprot - V9HWG0
swissprot - F8VNY3
swissprot - P45973
Ensembl - ENSG00000094916
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbx5ENSDARG00000061187Danio rerio
 CBX5ENSGALG00000036856Gallus gallus
 Cbx5ENSMUSG00000009575Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CBX1 / P83916 / chromobox 1ENSG0000010846862
CBX3 / Q13185 / chromobox 3ENSG0000012256561


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR008251  Chromo shadow domain
 IPR016197  Chromo-like domain superfamily
 IPR017984  Chromo domain subgroup
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0000118 histone deacetylase complex ISS
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0000792 heterochromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005720 nuclear heterochromatin TAS
 cellular_componentGO:0005721 pericentric heterochromatin ISS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0010369 chromocenter IEA
 cellular_componentGO:0016605 PML body IMP
 cellular_componentGO:0017053 transcriptional repressor complex ISS
 cellular_componentGO:0031618 nuclear pericentric heterochromatin NAS
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0035097 histone methyltransferase complex ISS
 cellular_componentGO:1990904 ribonucleoprotein complex IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030674 protein binding, bridging ISS
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0070491 repressing transcription factor binding ISS


Pathways (from Reactome)
Pathway description
SUMOylation of chromatin organization proteins
Transcriptional Regulation by E2F6
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex / reaction






 

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