ENSMUSG00000009575


Mus musculus

Features
Gene ID: ENSMUSG00000009575
  
Biological name :Cbx5
  
Synonyms : Cbx5 / Mus musculus chromobox 5 (Cbx5), transcript variant 4, mRNA. / Q61686
  
Possible biological names infered from orthology : chromobox 5 / P45973
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F3
Gene start: 103191544
Gene end: 103239816
  
Corresponding Affymetrix probe sets: 10433088 (MoGene1.0st)   1421933_at (Mouse Genome 430 2.0 Array)   1421934_at (Mouse Genome 430 2.0 Array)   1450416_at (Mouse Genome 430 2.0 Array)   1454636_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104441
Ensembl peptide - ENSMUSP00000113157
Ensembl peptide - ENSMUSP00000113158
Ensembl peptide - ENSMUSP00000120837
NCBI entrez gene - 12419     See in Manteia.
MGI - MGI:109372
RefSeq - XM_006520377
RefSeq - NM_001076789
RefSeq - NM_001110216
RefSeq - NM_001358950
RefSeq - NM_007626
RefSeq - XM_006520372
RefSeq - XM_006520374
RefSeq - XM_006520375
RefSeq - XM_006520376
RefSeq Peptide - NP_001070257
RefSeq Peptide - NP_001103686
RefSeq Peptide - NP_001345879
RefSeq Peptide - NP_031652
swissprot - Q61686
swissprot - D3Z0U2
Ensembl - ENSMUSG00000009575
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbx5ENSDARG00000061187Danio rerio
 CBX5ENSGALG00000036856Gallus gallus
 CBX5ENSG00000094916Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cbx1 / P83917 / Chromobox protein homolog 1 / P83916* / chromobox 1*ENSMUSG0000001866662
Cbx3 / chromobox protein homolog 3 / Q13185* / chromobox 3*ENSMUSG0000002983661


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR008251  Chromo shadow domain
 IPR016197  Chromo-like domain superfamily
 IPR017984  Chromo domain subgroup
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 cellular_componentGO:0000118 histone deacetylase complex IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0005721 pericentric heterochromatin IDA
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0010369 chromocenter IDA
 cellular_componentGO:0016605 PML body ISO
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 cellular_componentGO:0032991 protein-containing complex ISO
 cellular_componentGO:0035097 histone methyltransferase complex IDA
 cellular_componentGO:1990904 ribonucleoprotein complex ISS
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030674 protein binding, bridging IPI
 molecular_functionGO:0035064 methylated histone binding ISS
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043021 ribonucleoprotein complex binding ISS
 molecular_functionGO:0044877 protein-containing complex binding ISS
 molecular_functionGO:0070491 repressing transcription factor binding IPI


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mrap2tm1a(EUCOMM)Wtsi/Mrap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mrap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rock2Gt(OST440776)Lex/Rock2Gt(OST440776)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction






 

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