ENSG00000174197


Homo sapiens

Features
Gene ID: ENSG00000174197
  
Biological name :MGA
  
Synonyms : MGA / MGA, MAX dimerization protein / Q8IWI9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q15.1
Gene start: 41621224
Gene end: 41773081
  
Corresponding Affymetrix probe sets: 1564640_at (Human Genome U133 Plus 2.0 Array)   212945_s_at (Human Genome U133 Plus 2.0 Array)   235409_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457474
Ensembl peptide - ENSP00000457250
Ensembl peptide - ENSP00000483990
Ensembl peptide - ENSP00000219905
Ensembl peptide - ENSP00000442467
Ensembl peptide - ENSP00000455155
Ensembl peptide - ENSP00000456141
Ensembl peptide - ENSP00000457035
Ensembl peptide - ENSP00000457151
NCBI entrez gene - 23269     See in Manteia.
OMIM - 616061
RefSeq - XM_017022032
RefSeq - XM_011521398
RefSeq - XM_011521399
RefSeq - XM_011521400
RefSeq - XM_011521401
RefSeq - XM_017022028
RefSeq - XM_017022029
RefSeq - XM_017022030
RefSeq - XM_017022031
RefSeq - NM_001080541
RefSeq - NM_001164273
RefSeq - XM_005254243
RefSeq - XM_005254244
RefSeq - XM_005254245
RefSeq - XM_005254246
RefSeq - XM_005254247
RefSeq - XM_005254248
RefSeq - XM_005254249
RefSeq - XM_005254252
RefSeq - XM_005254253
RefSeq - XM_006720443
RefSeq - XM_006720445
RefSeq - XM_011521397
RefSeq Peptide - NP_001074010
RefSeq Peptide - NP_001157745
swissprot - H3BTN2
swissprot - H3BU53
swissprot - H3BP52
swissprot - A0A087X194
swissprot - Q8IWI9
swissprot - H3BTF4
Ensembl - ENSG00000174197
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgaaENSDARG00000078784Danio rerio
 ENSGALG00000031456Gallus gallus
 ENSGALG00000008653Gallus gallus
 MgaENSMUSG00000033943Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EOMES / O95936 / eomesoderminENSG000001635085
TBXT / O15178 / T-box transcription factor TENSG000001644585
TBR1 / Q16650 / T-box, brain 1ENSG000001365355
TBX19 / O60806 / T-box 19ENSG000001431785
TBX21 / Q9UL17 / T-box 21ENSG000000738614


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR018186  Transcription factor, T-box, conserved site
 IPR032060  Domain of unknown function DUF4801
 IPR036638  Helix-loop-helix DNA-binding domain superfamily
 IPR036960  T-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0071339 MLL1 complex IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100395 Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit  / reaction / complex
 ENSG00000125952 MAX / P61244 / MYC associated factor X  / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / reaction / complex
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / reaction / complex
 ENSG00000122565 CBX3 / Q13185 / chromobox 3  / complex / reaction
 ENSG00000156374 PCGF6 / Q9BYE7 / polycomb group ring finger 6  / complex / reaction
 ENSG00000015153 YAF2 / Q8IY57 / YY1 associated factor 2  / reaction / complex
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / reaction / complex
 ENSG00000121481 RNF2 / Q99496 / ring finger protein 2  / complex / reaction
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / complex / reaction
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / reaction / complex






 

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