ENSG00000163508


Homo sapiens

Features
Gene ID: ENSG00000163508
  
Biological name :EOMES
  
Synonyms : EOMES / eomesodermin / O95936
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p24.1
Gene start: 27715949
Gene end: 27722711
  
Corresponding Affymetrix probe sets: 231776_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295743
Ensembl peptide - ENSP00000388620
Ensembl peptide - ENSP00000487112
NCBI entrez gene - 8320     See in Manteia.
OMIM - 604615
RefSeq - XM_005265510
RefSeq - NM_001278182
RefSeq - NM_001278183
RefSeq - NM_005442
RefSeq Peptide - NP_001265112
RefSeq Peptide - NP_005433
RefSeq Peptide - NP_001265111
swissprot - O95936
Ensembl - ENSG00000163508
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eomesaENSDARG00000006640Danio rerio
 eomesbENSDARG00000104243Danio rerio
 EOMESENSGALG00000027247Gallus gallus
 EomesENSMUSG00000032446Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TBR1 / Q16650 / T-box, brain 1ENSG0000013653548
TBX21 / Q9UL17 / T-box 21ENSG0000007386133
MGA / Q8IWI9 / MGA, MAX dimerization proteinENSG0000017419721
TBX19 / O60806 / T-box 19ENSG0000014317817
TBXT / O15178 / T-box transcription factor TENSG0000016445816


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site
 IPR032385  T-box transcription factor-associated
 IPR036960  T-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001706 endoderm formation ISS
 biological_processGO:0001707 mesoderm formation ISS
 biological_processGO:0001714 endodermal cell fate specification IEA
 biological_processGO:0001824 blastocyst development IEA
 biological_processGO:0001829 trophectodermal cell differentiation IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0010002 cardioblast differentiation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0021772 olfactory bulb development IEA
 biological_processGO:0021796 cerebral cortex regionalization IEA
 biological_processGO:0021895 cerebral cortex neuron differentiation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032609 interferon-gamma production IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0060706 cell differentiation involved in embryonic placenta development ISS
 biological_processGO:0060809 mesodermal to mesenchymal transition involved in gastrulation ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding ISS
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding ISS
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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